Antitumor Activity of Asterriquinones from Aspergillus Fungi. IV. An Attempt to modify the Structure of Asterriquinones to increase the Activity
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概要
- 論文の詳細を見る
An attempt was made to obtain more potent antitumor compounds by chemically modifying asterriquinones. Amino-and aziridinyl-asterriquinone were newly synthesized, but showed no activity. However, dimethylallylation of asterriquinone Cl, which had no effect in vivo, yielded an active compound, with a change in pK_a value from 5.0 to 7.2. This suggests that other active compounds may be obtained by the chemical modification of asterriquinones with various other functional groups.
- 社団法人日本薬学会の論文
- 1982-05-25
著者
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山本 譲
Faculty of Pharmaceutical Sciences, Kanazawa Unversity
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清水 栄
Faculty of Pharmaceutical Sciences, Kanazawa University
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清水 栄
Faculty Of Pharmaceutical Sciences Kanazawa University
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越村 三郎
Kanazawa Medical University
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越村 三郎
Cancer Research Institute, Kanazawa University
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山本 譲
Faculty Of Pharmaceutical Sciences Kanazawa University
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