2-Thio-6-methyluracilのラットにおける代謝について
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概要
- 論文の詳細を見る
Metabolism of 6-methyl-2-thiouracil was studied in rats by using ^<14>C-labeled compound. Following the oral administration of 6-methyl-2-thiouracil [2-^<14>C] (490 mg/kg), the about 68% of the administered radioactivity was excreted in urine, 27% in feces, and 1.2% in respiratory CO_2 within 72 hr. After oral ingestion of the radioactive compound, radioactive substances excreted in urine after 48 hr were 6-methyl-2-thiouracil, 6-methyl-uracil, 6-methyl-2-methylthiouracil, 6-methyl-4-oxo-pyrimidine, 2-amino-6-methyl-4-oxopyrimidine, and urea which were present in about 46.2,9.1,1.6,1.8,0.2,and 0.8% of total radioactivity in the urine, respectively. In in vitro tests using rat liver slices, radioactivity was also detected in 5,6-dihydro-6-methyluracil along with the above metabolites.
- 社団法人日本薬学会の論文
- 1974-03-25
著者
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清水 栄
金沢大学薬学部臨床薬学教育センター
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清水 栄
Faculty Of Pharmaceutical Sciences Kanazawa University
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新田 啓一
Faculty of Pharmaceutical Sciences, Kanazawa University
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山本 譲
金沢大学薬学部
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加野 軒作
金沢大学薬学部
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植竹 厚子
金沢大学薬学部
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新田 啓一
金沢大学薬学部
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山本 譲
Faculty Of Pharmaceutical Sciences Kanazawa University
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新田 啓一
Faculty Of Pharmaceutical Sciences Kanazawa University
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