Trichothecium roseum LINKの代謝産物の研究Rosein IIIの構造
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概要
- 論文の詳細を見る
Rosein III, C_<20>H_<28>O_4,mp 226°, a metabolite of Trichothecium roseum LINK, was converted to ros-5,10-en-16-oic acid (9), and also more directly to a mixture of dihydrorosenono-(16) and dihydroisorosenono-lactone (17) via a novel cyclopropane intermediate (12). These correlations of rosein III with rosenonolactone (1) in association with the spectroscopic evidences of derivatives substantiated its structure and absolute configuration as 11-β-hydroxyrosenonolactone (2). The conformation of isorosein III, a C-8-isomer of rosein III, was also clarified as (14c) in which ring B has 7,10-RT-twist conformation.
- 公益社団法人日本薬学会の論文
- 1971-10-25
著者
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桐山 典城
Faculty of Pharmaceutical Sciences, Hokuriku University
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山本 譲
金沢大学薬学部
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津田 喜典
Faculty Of Pharmaceutical Sciences Kanazawa University
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山本 譲
Faculty Of Pharmaceutical Sciences Kanazawa University
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津田 喜典
昭和薬科大学
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桐山 典城
Faculty Of Pharmaceutical Sciences Kanazawa University
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桐山 典城
Faculty Of Pharmaceutical Sciences Hokuriku University
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