Preparation and Route of Asterriquinone Monoalkyl Ether from Asterriquinone Diacetate by Treatment with a Mixture of Alcohol and Alkali, Followed by Acidification

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概要

• 論文の詳細を見る

• 3-Alkoxy-6-hydroxy-p-benzoquinones were prepared by the treatment of 3,6-diacetoxy-p-benzoquinones with a mixture of alcohol and alkali, followed by acidification. The key intermediate acetoxy-alkoxy-p-benzoquinones were formed by the base-catalyzed addition of an alkoxy anion to the conjugated double bonds in the diacetoxy-p-benzoquinone ring, followed by an acetoxy anion elimination. This method was applied for preparing a novel o-quinone derivative of asterriquinone (ARQ) by the addition of 2-haloethanol and intramolecular O-alkylation.

• 公益社団法人日本薬学会の論文
• 1999-01-15

著者

• 鍛治 聡

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 桐山 典城

  Faculty of Pharmaceutical Sciences, Hokuriku University

• Saito Ryo

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Saito R

  Faculty Of Pharmaceutical Sciences Hokuriku University

• KAJI Akira

  Faculty of Pharmaceutical Sciences, Hokuriku University

• KIRIYAMA Noriki

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 桐山 典城

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Kaji A

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 鍛治 聡

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Kiriyama N

  Faculty Of Pharmaceutical Sciences Hokuriku University

• HATA(nee SHINBO)

  Faculty of Pharmaceutical Sciences, Hokuriku University

• Saito Ryo

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Hata(nee Shinbo)

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Hata Yukako

  Faculty of Pharmaceutical Sciences, Hokuriku University

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