Studies on Metabolites of Macrophoma commelinae. IV. : Substrate Specificity in the Biotransformation of 2-Pyrones to Substituted Benzoic Acids

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概要

• 論文の詳細を見る

• Substrate specificity in the novel biotransformation from 2-pyrone derivatives to substituted benzoic acids by Macrophoma commelinae (IFO 9570) was investigated by means of feeding experiments with various compounds. Among them, 2-pyrone derivatives substituted by an electron-donating group at C-4,by an electron-withdrawing group at C-5 and by an alkyl group at C-6 were converted to the corresponding benzoic acid derivatives in fairly good yields. The C_3-unit precursors and intermediates were examined in stationary or shaking culture. Based on the experimental results obtained, a mechanism for this unique reaction is proposed.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 山本 譲

  Faculty of Pharmaceutical Sciences, Kanazawa Unversity

• 宮嶋 久栄

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 清水 栄

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 清水 栄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 櫻井 郁男

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 秋山 克良

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 桜井 郁男

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 秋山 克良

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 山本 譲

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 荒井 健介

  東京薬科大学薬学部第2薬品分析化学教室

• 宮嶋 久栄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 山本 靖夫

  School Of Pharmaceutical Sciences Toho University

• 櫻井 郁男

  Faculty Of Pharmaceutical Sciences Kanazawa University

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