Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
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概要
- 論文の詳細を見る
Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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提 康央
Faculty Of Pharmaceutical Sciences Osaka University
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真弓 忠範
Faculty of Pharmaceutical Sciences
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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並川 眞知子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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水田 豊彦
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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井上 幸恵
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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柿内 雅
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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伊豆野 康広
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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山本 晋
Faculty of Pharmaceutical Sciences, Osaka University
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堤 康史
Faculty of Pharmaceutical Sciences, Osaka University
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中川 晋作
Faculty of Pharmaceutical Sciences, Osaka University
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並川 真知子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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YAMAMOTO Shinobu
Showa College of Pharmaceutical Sciences
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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中川 晋作
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Yamamoto Shuhei
Department Of Chemistry Graduate School Of Science Osaka City University
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堤 康史
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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山本 晋
Faculty Of Pharmaceutical Sciences Osaka University
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井上 幸恵
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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水田 豊彦
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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並川 真知子
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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伊豆野 康広
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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柿内 雅
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Yamamoto Shozo
Department Of Biochemistry Tokushima University School Of Medicine
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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