Amino Acids and Peptides. XVI. Synthesis of N-Terminal Tetrapeptide Analogs of Fibrin α-Chain and Their Inhibitory Effects on Fibrinogen : Thrombin Clotting

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概要

• 論文の詳細を見る

• N-Terminal tetrapeptide analogs of fibrin α-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.

• 公益社団法人日本薬学会の論文
• 1992-12-25

著者

• 川崎 紘一

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 辻 俊樹

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 平瀬 克彦

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 宮野 雅範

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 岩本 雅博

  Research Institute Daiichi Seiyaku Co. Ltd.

• 岩本 政博

  Research Institute Daiichi Seiyaku Co.. Ltd.

• 辻 俊樹

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 宮野 雅範

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 平瀬 克彦

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 宮野 雅則

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• Kawasaki Keiko

  Biological Science Laboratories Kao Corporation

• 川崎 紘一

  Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un

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