Enhancing Effect of α-Monoisostearyl Glyceryl Ether on the Percutaneous Penetration of Indomethacin through Excised Rat Skin
スポンサーリンク
概要
- 論文の詳細を見る
The enhancing effect of α-monoisostearyl glyseryl ether(GE-IS)on the percutaneous penatration of indomethacin(IM)from test solutions in propylene glycol(PG)was investigated using the excised abdominalskin of rats in vitro. The percutaneous penetration of IM into diffusion cells was significantly increased in the presence of 0.2% or 1%(w/w)GE-IS compared with enhancer-free PG solution. Permeation paramenters of IM, such as lag time and permeability coefficient, recealed that GE-IS signigivantly augmented the percutaneous penetration of IM from PG. These results strongly suggested that GE-}IS functions as a oenetration enhancer of IM through rat skin. To elucidate the mode od action of GE-IS as a penetration enhancer, the solubility of IM in the test solution and the percutaneous penetration of IM through damaged skin from which the stratum corneum had been stripped were investigated. The results suggested that GE-IS acts directly on the stratum corneum and alters the permebility of the skin.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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SUZUKI Atsushi
Biological Science Laboratories, Kao Corp.
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TOKIMITSU Ichiro
Biological Science Laboratories, Kao Corp.
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Hase Tadashi
Health Care Products Research Laboratories No.1 Kao Corporation
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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HASE Tadashi
Biological Science Laboratories, Kao Corporation
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KAWASAKI Keiko
Biological Science Laboratories, Kao Corporation
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YAMAGUCHI Tatsuyuki
Biological Science Laboratories, Kao Co.
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Suzuki Atsushi
Biological Science Laboratories Kao Co.
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Tokimitsu Ichiro
Health Care Food Research Laboratories Kao Corporation
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Tokimitsu Ichiro
Biological Science Laboratories Kao Corporation
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Yamaguchi T
Department Of Biological Science Teikyo University Of Science And Technology
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Hase Tadashi
Biological Science Laboratories Kao Corporation
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Takase Hideto
Health Care Products Research Laboratories No.1 Kao Corporation
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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