Amino Acids and Peptides. XXXI. Preparation of Analogs of the Laminin-Related Peptide YIGSR and Their Inhibitory Effect on Experimental Metastasis
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概要
- 論文の詳細を見る
Analogs of a partial sequence peptide of laminin, i.e., Tyr-Ile-Gly-Ser-Arg (YIGSR) analogs and Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (CDPGYIGSR) analogs, were prepared by the solid-phase method and their inhibitory effects on experimental metastasis of B16-BL6 melanoma cells were examined. YIGSR analogs in which Ile was replaced by other hydrophobic amino acids (Met, Leu, Phe) were inhibitory. Cys-containing analogs of YIGSR were also prepared, but were less active than the parent peptide, YIGSR. Among them, CYIGSR was easily oxidized to form a disulfide bond. A Cys-containing YIGSR analog cyclized through a disulfide bond, cyclo(CYIGSRC)G, was prepared. The disulfide bond formation was performed on the resin by the silyl chloride-sulfoxide method and by the iodine oxidation method. The yield of the silyl chloride-sulfoxide method was much better than that of the iodine oxidation method.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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村上 智彦
神戸学院大学 薬
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
Faculty Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Nakagawa Shinsaku
中華人民共和国
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Mukai Yohei
Graduate School Of Pharmaceutical Sciences Osaka University
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Mukai Yohei
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Tsutsumi Y
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kawai Y
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Kawai Yuichi
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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Morishita Yuki
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Morishita Yuki
大阪大学 薬学研究科毒性学
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TSUTSUMI Yasuo
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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MAYUMI Tadanori
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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KANEDA Yoshihisa
Faculty of Graduate School of Pharmaceutical Sciences, Osaka University
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Kawai Y
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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MU Yu
Faculty of Pharmaceutical Sciences, Osaka University
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IZUNO Yasuhiro
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Mu Yu
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Izuno Yasuhiro
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Tsutsumi Yasuo
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Kaneda Yoshihisa
Faculty Of Pharmaceutical Sciences Osaka University
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Kaneda Yoshihisa
Faculty Of Graduate School Of Pharmaceutical Sciences Osaka University
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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