Effects of Hydroxyhydroquinone-reduced Coffee on Blood Pressure in High-normotensives and Mild Hypertensives
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概要
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The influence of hydroxyhydroquinone (HHQ) on the antihypertensive effects of chlorogenic acids in coffee was evaluated in a double-blind, randomized controlled trial of high-normotensive and mild hypertensive adult men and women. The subjects were randomly assigned to either an active group that ingested HHQ-reduced coffee (0.05mg/184ml) containing chlorogenic acids (299mg/184ml) or a control group that ingested coffee containing HHQ (1.69mg/184ml) and chlorogenic acids (299mg/184ml), corresponding to commercially available products. Each subject was instructed to continuously ingest one can of test beverage (coffee) daily for 12 weeks. A linear mixed-model repeated-measures analysis of covariance of 38 high-normotensives and 60 mild hypertensives showed that systolic blood pressure (SBP) was significantly lower in the active group (n=51) than in the control group (n=47) throughout the intake period (Group effect; p=0.031). A stratified analysis suggested that the antihypertensive effect was greater in the mild hypertensives (Group effect; p=0.013 in SBP and p=0.015 in diastolic blood pressure) than in the high-normotensives. Safety assessment revealed no adverse effects associated with the reduction of HHQ to a level lower than the amounts in commercially available coffee products. These results suggest that HHQ-reduced coffee containing chlorogenic acids can be safely ingested to improve hypertension.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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ISHIMITSU Toshihiko
Dokkyo Medical University
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Ishimitsu Toshihiko
獨協医科大学 循環器内科
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Ishimitsu Toshihiko
東京大学 第2内科
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Ishimitsu Toshihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo University School Of Medicine
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OCHIAI Ryuji
Health Care Food Research Laboratories, Kao Corporation
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CHIKAMA Akiro
Health Care Food Research Laboratories, Kao Corporation
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KATAOKA Kiyoshi
Health Care Food Research Laboratories, Kao Corporation
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TOKIMITSU Ichiro
Health Care Food Research Laboratories, Kao Corporation
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Ochiai Ryuji
九州大学病院別府先進医療センター 循環呼吸老年病内科
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Ochiai Ryuji
Health Care Food Research Laboratories Kao Corporation
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Chikama Akiro
花王ヘルスケア食品研究所
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Chikama Akiro
Health Care Food Research Laboratories Kao Corporation
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Ochiai Ryuji
Biological Science Laboratories Kao Corp.
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Yamaguchi Tohru
Health Care Food Research Laboratories Kao Corporation
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Kataoka Kiyoshi
Health Care Food Research Laboratories Kao Corporation
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Tokimitsu Ichiro
Health Care Food Research Laboratories Kao Corporation
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Abe Chiaki
Health Care Products Research Laboratories Kao Corporation
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Ishiguro Toshiya
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Ikeda T
東京大学 第2内科
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