Valsartan improves L-NAME-exacerbated cardiac fibrosis with TGF-β inhibition and apoptosis induction in spontaneously hypertensive rats
スポンサーリンク
概要
- 論文の詳細を見る
- 2008-12-15
著者
-
ISHIMITSU Toshihiko
Dokkyo Medical University
-
Muratani H
Department Of Clinical Pharmacology And Therapeutics Tohoku University
-
MATSUOKA Hiroaki
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
-
Makino H
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine And Denti
-
Matsuoka Hiroaki
大阪大学 医学系研究科老年・腎臓内科学
-
Ishimitsu Toshihiko
獨協医科大学 循環器内科
-
Ishimitsu Toshihiko
東京大学 第2内科
-
Ishimitsu Toshihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Ishimitsu Toshihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo University School Of Medicine
-
ONO Hidehiko
Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University Scho
-
Ono Yuko
Department of Pathology, Dokkyo Medical University
-
Akashiba Akira
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine
-
Horio M
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Pharmaceut
-
Makino Hirofumi
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine Dentistry
-
Matsuoka H
Kyoto Univ. Kyoto
-
Ono Yuko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Ono Yuko
Department Of Geriatric And Environmental Dermatology Nagoya City University Graduate School Of Medi
-
Ono Hidehiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Hiroe Michiaki
Second Department Of Internal Medicine Tokyo Medical And Dental University
-
Akashiba Akira
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Matsuoka Hiroaki
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
-
Ishiguro Toshiya
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Ikeda T
東京大学 第2内科
-
Matsuoka Hiroaki
Department Of Bioscience National Cardiovascular Center Research Institute
-
Ishimitsu Toshihiko
Department of Cardiology and Nephrology, Dokkyo Medical University School of Medicine
-
Ishimitsu Toshihiko
Department of Cardiology and Nephrology, Dokkyo Medical University
関連論文
- PE-404 Improvement of γ-glutamyl Transferase Activity by CPAP may Reduce Cardiovascular Risk in Patients with Obstructive Sleep Apnea(PE068,Obesity/SAS 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study
- Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study
- A Simple Risk Score to Predict In-Hospital Death of Elderly Patients With Acute Decompensated Heart Failure : Hypoalbuminemia as an Additional Prognostic Factor
- Erythropoietin in Patients With Acute Coronary Syndrome and Its Cardioprotective Action After Percutaneous Coronary Intervention
- Subacutely progressed extensive aortic dissection complicated with catheter-induced dissection in left main coronary artery
- The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome : the Ohasama study
- Effects of Long-Term Intravenous Administration of Adrenomedullin (AM) Plus hANP Therapy in Acute Decompensated Heart Failure : A Pilot Study
- PJ-733 Independent Risk for Chronic Kidney Disease in 824 Adult Patients(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-713 Seasonal Mortality Variation in Out-of-hospital Cardiac Arrest : Analysis from AMI-Kyoto Multi-Center Risk Study Database(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-675 Deletion of Fc Receptor Reduces Atherosclerotic Lesions in LDL Receptor Knockout Mice : Role of Protection against Inflammation and Oxidative Stress(PJ113,Atherosclerosis, Basic 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- PJ-635 Effect of Olmesartan on Tissue Expression Balance between Angiotensin II Receptor and Its Inhibitory Binding Molecule(PJ107,Cardiomyopathy/Hypertrophy (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-584 Contributing Factors for the Incidence of Paroxysmal Atrial Fibrillation in Patients with Obstructive Sleep Apnea(PJ098,Obesity/SAS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-531 Lipid Profile and Importance of LDL/HDL Ratio in 770 Patients with Acute Coronary Syndrome(PJ089,Atherosclerosis (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-513 Hyponatremia is an Important Predictor for In-hospital Mortality in Heart Failure Patients with Preserved Ejection Fraction(PJ086,Heart Failure (Treatment) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PJ-383 Predictors of In-Hospital Prognosis after Primary Percutaneous Coronary Intervention for Repeat Myocardial Infarction : Insights from the AMI-Kyoto Multi-Center Risk Study(PJ065,ACS/AMI (Clinical/Treatment) 3 (IHD),Poster Session (Japanese),The 73r
- PJ-117 FGF Receptor Signals in Endothelial Cells Aggravates High Cholesterol Diet-Mediated Atherosclerosis through Dysfunction of Endothelial Cell and VSMC Proliferation(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scient
- PE-552 Left Atrial Volume by Real-time Three-Dimensional Echocardiography : Validation by 64-slice Multidetector Computed Tomography(PE093,Echo/Doppler (Others) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation So
- PE-460 Prehospital Delay Time and the Rate of Ambulance User for Acute Myocardial Infarction were not Improved from 2000-2007 in Kyoto(PE077,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- Clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease
- Role of diabetes and obesity in outcomes of the candesartan antihypertensive survival evaluation in Japan (CASE-J) trial
- Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
- A case of Takayasu's arteritis and aortic regurgitation, which presented much difficulty in the diagnosing process because of complicated osteomyelitis and non-typical manifestations
- Right atrial abnormalities in a patient with arrhythmogenic right ventricular cardiomyopathy without ventricular tachycardia
- PE-288 High-sensitivity C-reactive Protein Could Reflect Coronary Atherosclerosis in the Ischemic Heart Disease(Chronic coronary heart disease/Remodeling(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- PE-279 Carvedilol in Idophasic Dilated Cardiomyopathy : is It Possible to Identify Factors Predictive of Improvement of LVEF?(Cardiomyopathy, basic/clinical(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients : Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study
- Urinary excretion of liver fatty acid-binding protein in health-check participants
- Predictors of In-Hospital Prognosis After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Requiring Mechanical Support Devices
- Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease
- Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension
- PJ-713 Seasonal Mortality Variation in Out-of-hospital Cardiac Arrest : Analysis from AMI-Kyoto Multi-Center Risk Study Database(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-588 Rehabilitation after Angiogenic Cell Therapy for the Critical Limb Ischemia(PJ099,Exercise Test/Cardiac Rehabilitation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-513 Hyponatremia is an Important Predictor for In-hospital Mortality in Heart Failure Patients with Preserved Ejection Fraction(PJ086,Heart Failure (Treatment) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PJ-461 Aerobic Exercise in the Postoperative Cardiac Rehabilitation did not Deteriorate Renal Function in the Patients with Renal Failure(PJ078,Kidney/Renal Circulation/CKD 4 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-383 Predictors of In-Hospital Prognosis after Primary Percutaneous Coronary Intervention for Repeat Myocardial Infarction : Insights from the AMI-Kyoto Multi-Center Risk Study(PJ065,ACS/AMI (Clinical/Treatment) 3 (IHD),Poster Session (Japanese),The 73r
- PJ-117 FGF Receptor Signals in Endothelial Cells Aggravates High Cholesterol Diet-Mediated Atherosclerosis through Dysfunction of Endothelial Cell and VSMC Proliferation(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scient
- PE-460 Prehospital Delay Time and the Rate of Ambulance User for Acute Myocardial Infarction were not Improved from 2000-2007 in Kyoto(PE077,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- PE-394 p53 and SCO2 (Synthesis of Cytochrome c Oxidase 2) Augment the Progression of Diabetic Cardiomyopathy(PE066,Diabetes 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-133 Calcium-Dependent Tyrosine-Kinase PYK2 Plays Crucial Role in Angiotensin II- but Not Norepineprine-Mediated Activation of Rac/Superoxide-Pathway that Differentially Regulates Blood Pressure(OJ23,Hypertension, Basic (H),Oral Presentation (Japanese),
- OJ-105 Diversity of Molecular Forms of BNP in Heart Failure : Difference of Molecular Form of BNP in Atrial and Ventricular Overload(OJ18,Heart Failure (Laboratory/Biomarkers) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japa
- OJ-058 Bone Marrow AT1 Receptor Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitor Cells in a Platelet-Derived SDF-1α-Dependent Manner(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientifi
- OJ-023 Intermediate Fixed Coronary Stenosis at a Site of Ergonovine-Provoked Spasm as a Predictor of the Long-Term MACE of CSA Patients(OJ04,Angina Pectoris (Basic, Clinical) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Jap
- PJ-713 Seasonal Mortality Variation in Out-of-hospital Cardiac Arrest : Analysis from AMI-Kyoto Multi-Center Risk Study Database(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-513 Hyponatremia is an Important Predictor for In-hospital Mortality in Heart Failure Patients with Preserved Ejection Fraction(PJ086,Heart Failure (Treatment) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PJ-461 Aerobic Exercise in the Postoperative Cardiac Rehabilitation did not Deteriorate Renal Function in the Patients with Renal Failure(PJ078,Kidney/Renal Circulation/CKD 4 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-383 Predictors of In-Hospital Prognosis after Primary Percutaneous Coronary Intervention for Repeat Myocardial Infarction : Insights from the AMI-Kyoto Multi-Center Risk Study(PJ065,ACS/AMI (Clinical/Treatment) 3 (IHD),Poster Session (Japanese),The 73r
- PJ-117 FGF Receptor Signals in Endothelial Cells Aggravates High Cholesterol Diet-Mediated Atherosclerosis through Dysfunction of Endothelial Cell and VSMC Proliferation(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scient
- PE-460 Prehospital Delay Time and the Rate of Ambulance User for Acute Myocardial Infarction were not Improved from 2000-2007 in Kyoto(PE077,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- OJ-133 Calcium-Dependent Tyrosine-Kinase PYK2 Plays Crucial Role in Angiotensin II- but Not Norepineprine-Mediated Activation of Rac/Superoxide-Pathway that Differentially Regulates Blood Pressure(OJ23,Hypertension, Basic (H),Oral Presentation (Japanese),
- OJ-105 Diversity of Molecular Forms of BNP in Heart Failure : Difference of Molecular Form of BNP in Atrial and Ventricular Overload(OJ18,Heart Failure (Laboratory/Biomarkers) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japa
- OJ-058 Bone Marrow AT1 Receptor Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitor Cells in a Platelet-Derived SDF-1α-Dependent Manner(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientifi
- OJ-023 Intermediate Fixed Coronary Stenosis at a Site of Ergonovine-Provoked Spasm as a Predictor of the Long-Term MACE of CSA Patients(OJ04,Angina Pectoris (Basic, Clinical) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Jap
- Green Coffee Bean Extract Improves Human Vasoreactivity
- Leptin Gene and Leptin Receptor Gene Polymorphisms Are Associated with Sweet Preference and Obesity
- Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure
- 1 Role of the Ubiquitin Proteasome System in the Development of Heart Failure in Hypertrophic Cardiomyopathy(Young Investigator's Award for International Students Finalists Lecture (YIA International),Special Program,The 72nd Annual Scientific Meeting of
- Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction
- Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan : Diurnal variations in blood pressure : clinical implications and pathogenesis
- Practice and awareness of physicians regarding home blood pressure measurement in Japan
- Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate
- OE-193 Exaggeration of Remote Reperfusion Pulmonary Injury in AMP Deaminase 3 Knockout Mice(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Exercise-Induced U-Wave Changes in Patients With Coronary Artery Disease : Correlation With Tomographic Thallium-201 Myocardial Imaging
- Exercise-Induced ST-Segment Elevation : Role of Left Ventricular Wall Motion Abnormalities and Coronary Artery Narrowing
- Neurohumoral Factor Responses to Mental (Arithmetic) Stress and Dynamic Exercise in Normal Subjects
- -P625- COULD NITRATE TOLERANCE DEVELOP TO THE CORONARY VASODILATIVE EFFECTS OF ORAL LONG-ACTING ISOSORBIDE DINITRATE?(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1236- RESPONSES IN NEUROHORMONAL FACTORS DURING EXERCISE IN PATIENTS WITH ESSENTIAL HYPERTENSION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1078- Augmented Sympathetic Response to Imbalance in the Supply of ATP during Maximal Exercise in Patients with Heart Failure(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- PERFUSION RESERVE OF CORONARY COLLATERAL CIRCULATION AND ITS SIGNIFICANCE IN THE DEVELOPMENT OF EXERCISE-INDUCED ISCHEMIA IN PATIENTS WITH MULTIVESSEL DISEASE
- PERFUSION RESERVE OF CORONARY COLLATERAL CIRCULATION AND ITS SIGNIFICANCE IN THE DEVELOPMENT OF EXERCISE-INDUCED ISCHEMIA IN PATIENTS WITH MULTIVESSEL DISEASE
- CLINICAL SIGNIFICANCE OF THE AMMONIA RESPONSE TO EXERCISE IN PATIENTS WITH CONGESTIVE HEART FAILURE
- EFFECTS OF VOLUME AND PRESSURE OVERLOADS AND MYOCARDIAL HYPERTROPHY ON EXERCISE-INDUCED CHANGES IN ELECTROCARDIOGRAPHIC QRS AMPLITUDE
- PLASMA CATECHOLAMINE RESPONSES TO DYNAMIC EXERCISE IN PATIENTS WITH CORONARY ARTERY DISEASE : The Relationship between Sympathetic Activity and Systolic Blood Pressure and Exercise-induced Ventricular Arrhythmias
- SIGNIFICANCE OF CORONARY ARTERY TONE ASSESSED BY CORONARY RESPONSES TO ERGONOVINE AND NITRATE
- PE-380 Cardio Ankle Vascular Index (CAVI) is Useful Index for Evaluating Coronary Risk(Atherosclerosis, clinical(07)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-310 Telmisartan Enhances Endothelial Progenitor Cells via PPAR-gamma in Rat Hindlimb Ischemia(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-413 Eplerenone Enhances Neovascularization Induced by Endothelial Progenitor Cells in Rat Hindlimb Ischemia(Atherosclerosis, basic(07)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-392 Effect of Combination Therapy with Bone-Marrow Mononuclear Cells Implantation and Sarpogrelate Hydrochloride on Angiogenesis and Cardiac Performance in Myocardial Ischemia(PJ066,ACS/AMI (Basic) (IHD),Poster Session (Japanese),The 73rd Annual Scient
- 2 Cariorenal Association in Prognosis of Chronic Cardiovascular Disease and Renal Disease : Significance of Neurohumoral Activation(Cardiorenal Syndrome and Hypertensive Heart Diseases, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- Relationship of dysregulation of glucose metabolism with white-coat hypertension : the Ohasama study
- Relations of Blood Pressure Values to the Risks of Death and Cardiovascular Events in Chronic Hemodialysis Patients(Hypertension, Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Valsartan on the Progression of Chronic Renal Insufficiency in Patients with Nondiabetic Renal Diseases
- 2-hour Postchallenge Blood Glucose was More Closely Related to Brachial-ankle Pulse Wave Velocity than Fasting Blood Glucose in Japanese Men (Diabetes/Obesity 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Present Status of Blood Pressure Control in a Group of Hypertensive Patients Followed-up in a Cardiovascular Outpatient Clinic
- Predictive Significance of Blood Pressure Values for the Incidence of Cardiovascular Events in Chronic Hemodialysis Patients
- PE-105 Influence of Anemia and Inflammation on the Risks of Death and Cardiovascular Events in Chronic Hemodialysis Patients(Kidney/Renal circulation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-161 Smoking Habits Deteriorate Arterial Compliance and Increase Central Blood Pressure despite a Similar Effect on Brachial Blood Pressure(Smoking(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood
- Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis
- Valsartan improves L-NAME-exacerbated cardiac fibrosis with TGF-β inhibition and apoptosis induction in spontaneously hypertensive rats
- evidence-based practice guideline for the treatment of chronic kidney disease
- Effects of Imidapril on Left Ventricular Mass in Chronic Hemodialysis Patients
- Protective Effects of an Angiotensin II Receptor Blocker and a Long-Acting Calcium Channel Blocker against Cardiovascular Organ Injuries in Hypertensive Patients
- Effects of Hydroxyhydroquinone-reduced Coffee on Blood Pressure in High-normotensives and Mild Hypertensives
- PE-466 Clinical Usefulness of a Newly Developed Instrument for Non-invasive Monitoring of Beat-by-beat Cardiovascular Hemodynamic Parameters(Cardiac Function, Basic/Clinical 3 (M) : PE79)(Poster Session (English))
- OJ-248 Losartan Reduced Massive Proteinuria in Chronic Renal Disease Patients with Lower Renal Tissue TGF-beta1 mRNA Levels(Hypertension, Clinical 5 (H) : OJ29)(Oral Presentation (Japanese))