SIGNIFICANCE OF CORONARY ARTERY TONE ASSESSED BY CORONARY RESPONSES TO ERGONOVINE AND NITRATE

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概要

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• The coronary artery response to ergonovine ( EM ) and nitrate of the proximal. middle and distal segments of the three major coronary artery branches and the main trunk was quantified in 67 patients without coronary spasm and in 69 patients with coronary spasm without significant organic stenosis. The changes in control diameter and diameter after EM administration compared to diameter after nitrate were used as the index of coronary artery tone. EM increased coronary artery tone regardless of the occurrence of coronary spasm (p<0.01). In all segments, basal coronary artery tone was greater in patients with spasm than in patients without spasm (p<0.01) in a way similar to the coronary responses to EM (p<0.01). In patients with spasm, both coronary artery tone after EM and basal coronary tone were greater in the spastic segments than in the nonspastic segments (p<0.01), which were greater than those in patients without spasm (p<0.01). Our data suggest that patients with spasm may have in-creased basal tone, and that coronary artery spasm may be based on increased coronary tone. Clinically, evaluation of the basal tone and response to EM in the entire coronary artery tree may be useful for predicting the presence of coronary artery spasm.

• 社団法人日本循環器学会の論文
• 1991-01-20

著者

• Muratani H

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• Miyakoda Hiroyuki

  Department Of Bioscience National Cardiovascular Center

• Hoshio Akira

  First Department of Internal Medicine, Tottori University

• HOSHIO AKIRA

  Department of Internal Medicine, Tottori University School of Medicine

• FUKUKI MASAHARU

  Department of Internal Medicine, Tottori University School of Medicine

• YAMASAKI JUNICHI

  Department of Internal Medicine, Tottori University School of Medicine

• KOTAKE HIROSHI

  Department of Internal Medicine, Tottori University School of Medicine

• MASHIBA HIROTO

  Department of Internal Medicine, Tottori University School of Medicine

• HIROE Koh

  First Department of Internal Medicine, Tottori University Faculty of Medicine

• Fukuki Masaharu

  The First Department Of Internal Medicine Faculty Of Medicine Tottori University

• Fukui Masaharu

  The First Department Of Internal Madicine Tottori University

• Hoshio Akira

  First Department Of Internal Medicine Tottori University

• Miyakoda Hiroyuki

  The First Department Of Internal Medicine Tottori University School Of Medicine

• Hiroe Koh

  First Department Of Internal Medicine Tottori University Faculty Of Medicine

• Hoshio Akira

  The First Department Of Internal Medicine Tottori University School Of Medicine

• Hoshio Akira

  First Department Of Internal Medicine Tottori University School Of Medicine

• Yamasaki Junichi

  Department Of Internal Medicine Tottori University School Of Medicine

• Mashiba Hiroto

  Department Of Bioscience National Cardiovascular Center Research Institute

• Mashiba Hiroto

  1st Department Of Internal Medicine Tottori University School Of Medicine

• Kotake Hiroshi

  First Department Of Internal Medicine Tottori University School Of Medicine

• Kotake Hiroshi

  Dept Of Internal Medicine Tottori Univ.

• Kotake Hiroshi

  Department of Chemistry, Faculty of Science, Kanazawa University

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