Effect of Class I Antrarrhythmic Agents on Slow Ca^<2+> Channels of Myocardial Cells : SYMPOSIUM ON HIGH RISK ARRHYTHMIA ITS MECHANISM AND TREATMENT : 51th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
The effect of several class I antiarrhythmic drugs (aprindine, cibenzoline, disopyramide, mexiletine, lidocaine, tocainide and 711389-S) were studied on slow Ca^<2+> channels of rabbit sinus node cells using a double microelectrode voltage clamp technique. All these drugs decreased the heart rate, the maximum rate of rise (V^^・max), the action potential amplitude and the slope of the phase 4 depolarization in spontaneously beating sinus node preparations. The order of inhibitory potency on the heart rate was: aprindine > 711389-S > cibenzoline ⩾ disopyramide > mexiletine ⩾ lidocaine > tocainide. On the current systems, these drugs decreased the slow inward current (I^<si>) and the time-dependent potassium current (I_k). However, the major effect was a reduction of I_<si>. These agents also exerted a frequency-dependent block of I_<si>. furthermore, comparing the effects of class I antiarrhythmic agents on slow Ca^<2+> channels, the order of inhibitory effects on V^^max of sinus node cells was: aprindine > 711389-S > cibenzoline ⩾ disopyramide > mexiletine > tocainide. These electrophysiological observations suggest that class I antiarrhythmic drugs have a depressant effect on slow Ca^<2+> channels as well as fast Na^+ channels of myocardial cells, and that so-calledslowkinetic drugs may depress slow Ca^<2+> channels more strongly thanfastkinetic drugs.
- 社団法人日本循環器学会の論文
- 1988-03-20
著者
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Muratani H
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Hasegawa Junichi
Dept.of Internal Medicine Saihaku Hospital
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Hasegawa Junichi
Dept Of Internal Medicine Saihaku Hospital
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Mashiba Hiroto
The 1st Department of Internal Medicine, Tottori University School of Medicine
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KOTAKE Hiroshi
The 1st Dept. Intern. Med. Tottori Univ. School of Med.
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HASEGAWA JUNICHI
The 1 st Department of Internal Medicine Tottori University School of Medicine
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Hiroe Koh
First Department Of Internal Medicine Tottori University Faculty Of Medicine
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Kotake Hiroshi
The First Department Of Internal Medicine Tottori University School Of Medicine
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Mashiba Hiroto
1st Department Of Internal Medicine Tottori University School Of Medicine
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Kotake Hiroshi
Dept Of Internal Medicine Tottori Univ.
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