Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate
スポンサーリンク
概要
- 論文の詳細を見る
Background Remote reperfusion lung injury occurs in patients with vascular occlusion and surgical procedures. Inosine monophosphate (IMP) produced by adenosine monophosphate deaminase (AMPD) 3 is involved in the remote reperfusion injury. The purpose of the present study was to identify whether IMP administration attenuated the remote reperfusion lung injury in a skeletal muscle ischemia-reperfusion model. Methods and Results A remote reperfusion lung injury was created using reperfusion after the bilateral ligation of the hind-limb. AMPD activity, myeloperoxidase (MPO) activity, IMP, AMPD3 mRNA and tumor necrosis factor (TNF)-α in the lungs before and after reperfusion were analyzed. Furthermore, the effects of IMP on these parameters were examined. AMPD3 mRNA, AMPD activity and IMP production in the lungs significantly increased after ischemia-reperfusion with increases in MPO activity, TNF-α level and decreased oxygen saturation (SpO_2). Histological examination of the lungs demonstrated significant neutrophil infiltration and accumulation. IMP administration significantly reduced MPO activity, TNF-α and neutrophil infiltration, with ameliorated SpO_2. Conclusions Along with the activation of AMPD3, ischemia-reperfusion-induced lung inflammation is associated with increased MPO activity and TNF-α level. IMP significantly decreased the lung injury, MPO activity, TNF-α and increased SpO_2. These findings may lead to the development of a new therapeutic strategy for remote reperfusion lung injury.
- 社団法人日本循環器学会の論文
- 2007-03-20
著者
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IIMURA Osamu
Sapporo Medical University
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Ogino Kazuhide
Center for Clinical Residency Program, Tottori University Hospital
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Hisatome Ichiro
Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of
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Shigemasa Chiaki
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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MORISAKI Takayuki
Department of Biosciences, Research Institute, National Cardiovascular Center
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Muratani H
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Shigemasa Chiaki
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Shigemasa Chiaki
鳥取大学 医学部循環器内科
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Shigemasa Chiaki
Division Of Regenerative Medicine And Therapeutics Department Of Genetic Medicine And Regenerative M
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Shigemasa Chiaki
鳥取大学 医学部病院薬剤部
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Itoh Hiroshi
Division 1 Department Of Pathology Kobe University School Of Medicine
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Igawa Osamu
Division of Molecular Medicine and Therapeutics, Tottori University
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Igawa Osamu
Sapporo Medical University
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Iimura Osamu
The 2nd Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Miyata Toshiyuki
Research Institute National Cardiovascular Center
-
Hoshikawa Yoshiko
Department Of Biosignaling Faculty Of Medicine Tottori University
-
Li Peili
Department Of Genetic Medicine And Regenerative Therapeutics Institute Of Regenerative Medicine And
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Ninomiya Haruaki
鳥取大学 遺伝子再生医療学
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Ninomiya H
Department Of Neurobiology Faculty Of Medicine Tottori University
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Ninomiya Haruaki
Department Of Biological Regulation Tottori University Faculty Of Medicine
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Ninomiya Haruaki
鳥取大学医学部附属脳幹性疾患研究施設 脳神経小児科部門
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Ogino Kazuhide
Center For Clinical Residency Program Tottori University Hospital
-
Hoshikawa Yoshiko
Division Of Molecular And Genetic Medicine Department Of Genetic Medicine And Regenerative Therapeut
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Miyakoda Hiroyuki
Department Of Bioscience National Cardiovascular Center
-
Morisaki Hiroko
Department Of Bioscience Research Institute National Cardiovascular Center
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Morisaki Takayuki
国立循環器病センター 心臓血管内科
-
Morisaki Takayuki
Department Of Biosciences Research Institute National Cardiovascular Center
-
Morisaki Takayuki
Department Of Bioscience Department Of Cardiovascular Surgery
-
Iimura O
Sapporo Medical Univ.
-
Hisatome Ichiro
First Department Of Internal Medicine Faculty Of Medicine Tottori University
-
Horio M
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Pharmaceut
-
Miyata Toshiyuki
Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
-
Iimura O
Sapporo Medical University
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Morisaki T
Department Of Bioscience National Cardiovascular Center Research Institute
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Iimura Osamu
The 2nd Department Of Internal Medicine Sapporo Medical College. Sapporo. Japan
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Iimura Osamu
Second Department Of Internal Medicine Sapporo Medical College
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Li Peili
Division of Molecular Medicine and Therapeutics, Tottori University
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Cheng Jidong
Department of Bioscience, National Cardiovascular Center
-
Toyama Keiko
Genetic Engineering and Functional Genomics Unit, Horizontal Medical Research Organization, Kyoto Un
-
Hashimoto Kiyoshi
Division of Internal Medicine and Molecular Therapeutics, Tottori University
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Ninomiya Haruaki
Division of Neurobiology, Department of Biomedical Sciences, Tottori University
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Tomikura-Shimoyama Yoko
Division of Molecular Medicine and Therapeutics, Tottori University
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Mashiba Hiroto
Kure Kyosai Hospital
-
Tomikura Yoko
Division of Molecular Medicine and Therapeutics, Tottori University
-
Peili Li
Division Of Molecular Medicine And Therapeutics Department Of Multidisciplinary Internal Medicine To
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Takano Makoto
Division Of Molecular Physiology And Biophysics Department Of Physiology Jichi Medical University
-
Takano M
Division Of Biophysics Department Of Physiology Jichii Medical School
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Mannami Toshifumi
Department Of Preventive Cardiology National Cardiovascular Center
-
Morisaki Hiroko
Department Of Bioscience Department Of Cardiovascular Surgery
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Hashimoto Kiyoshi
Division Of Internal Medicine And Molecular Therapeutics Tottori University
-
Cheng Jidong
Department Of Bioscience National Cardiovascular Center
-
Toyama Keiko
Genetic Engineering And Functional Genomics Unit Horizontal Medical Research Organization Kyoto Univ
-
Miyata Toshiyuki
Department Of Preventive Cardiology National Cardiovascular Center:hygiene And Public Health Social
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Yokoyama Hitoshi
Division Of Nephrology Kanazwa Medical University
-
Kosaka Hiromoto
The First Department Of Medicine Tottori University School Of Medicine
-
Morisaki Takayuki
Department Of Medicine University Of Pennsylvania
-
Ninomiya Haruaki
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
-
Miyake Takashi
Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
-
Shigemasa Chiaki
Division Of Regenerative Medicine And Therapeutics Department Of Genetic Medicine And Regenerative M
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Ito Hisao
Division Of Organ Pathology Department Of Microbiology And Pathology Faculty Of Medicine Tottori Uni
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Miura Toshie
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Shigemasa Chiaki
Division Of Regenerative Medicine And Therapeutics Department Of Genetic Medicine And Regenerative Medicine And Therapeutics Institute Of Regenerative Medicine And Biofunction Tottori University Graduate School Of Medical Science
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Hisatome Ichiro
Department Of Cardiology Kitano Hospital Medical Research Institute
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MORISAKI Takayuki
Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute
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Igawa Osamu
Division of Cardiovascular Medicine, Department of Internal Medicine, Tottori University Faculty of Medicine
-
Shigemasa Chiaki
Division of Cardiovascular Medicine, Department of Internal Medicine, Tottori University Faculty of Medicine
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MORISAKI Hiroko
Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute
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