Neurohumoral Profiles in Patients With Hypertrophic Cardiomyopathy : Differences to Hypertensive Left Ventricular Hypertrophy
スポンサーリンク
概要
- 論文の詳細を見る
Background Patients with hypertrophic cardiomyopathy (HCM) or hypertensive heart disease (HHD) have increased concentrations of various neurohumoral factors. Thus, the aim of the present study was to evaluate the differences in the neurohumoral profiles of HCM and HHD. Methods and Results Plasma concentrations of epinephrine, norepinephrine, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), angiotensin II and endothelin-1 were measured in 40 patients with HCM, 35 with HHD, and 15 controls. Additionally, the concentrations of these neurohumoral factors in the coronary sinus and aortic root were measured in 12 HCM patients and 10 controls. Plasma concentrations of norepinephrine, ANP and BNP were significantly higher in HCM than HHD and controls. In HCM, there was no significant correlation between the left ventricular mass index and any neurohumoral factor. The plasma BNP concentration significantly correlated with left intraventricular pressure gradient in HCM. There were significant differences in the plasma concentrations of ANP and BNP between HCM with and without left ventricular diastolic dysfunction. Transcardiac production of BNP was significantly higher in patients with obstructive HCM than in those with non-obstructive HCM. Conclusions The significant neurohumoral differences between HCM and HHD were the plasma concentrations of norepinephrine, ANP and BNP. In HCM patients, the plasma BNP concentration may reflect the intraventricular pressure gradient and left ventricular diastolic dysfunction whereas the plasma ANP concentration reflects only the left ventricular diastolic dysfunction.
- 社団法人日本循環器学会の論文
- 2004-04-20
著者
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Ogino Kazuhide
Center for Clinical Residency Program, Tottori University Hospital
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Kato Masahiko
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Furuse Yoshiyuki
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Kinugasa Yoshiharu
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Hisatome Ichiro
Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of
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Shigemasa Chiaki
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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IGAWA Osamu
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Shigemasa Chiaki
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Itoh Hiroshi
Division 1 Department Of Pathology Kobe University School Of Medicine
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Igawa Osamu
Sapporo Medical University
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OGINO Kazuhide
Department of Cardiovascular Medicine, Tottori University Faculty of Medicine
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Ogino Kazuhide
Center For Clinical Residency Program Tottori University Hospital
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Ogura Kazuyoshi
Department of Cardiovascular Medicine, Tottori University Hospital
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Kinugawa Toru
Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Kato Masahiko
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Osaki Shuichi
Department Of Cardiology San-in Rosai Hospital
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Kinugawa Toru
Kitano Hospital
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Tomikura Yoko
Department of Cardiovascular Medicine, Tottori University
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Tomikura Yoko
Division of Molecular Medicine and Therapeutics, Tottori University
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Kinugawa Tooru
Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Kinugasa Yoshiharu
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Kato Masahiko
Department Of Allergy And Immunology Gunma Children's Medical Center
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Kinugawa Toru
Dept. Of Internal Medicine Tottori Univ.
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Furuse Yoshiyuki
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Igawa Osamu
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Hisatome Ichiro
Department Of Cardiology Kitano Hospital Medical Research Institute
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