Obstructive Sleep Apnea and Cardiovascular Disease
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概要
- 論文の詳細を見る
Over the past few decades, sleep apnea has emerged as an important potential etiologic factor in a broad range of cardiac and vascular diseases. These disease conditions include hypertension, coronary artery disease, myocardial infarction, heart failure, and stroke. Recognition of the role of sleep apnea in clinical cardiology is also increasing in Japan. Although sleep apnea has been strongly linked to obesity in Western populations, in Japanese and other Asian populations there is evidence to indicate that sleep apnea may be prevalent even at lower levels of obesity. In this review we address the epidemiology of sleep apnea. Since sleep apnea includes the combined stresses of hypoxemia, apnea, and disrupted sleep, we also review briefly the potential disease mechanisms that may be activated as a consequence of sleep apnea. We further examine the role of sleep apnea in the pathophysiology and management of specific cardiovascular conditions. Overall, while the evidence of sleep apnea as a causal mechanism in cardiovascular disease is strong and increasing, definitive evidence of the etiologic role of sleep apnea has yet to be obtained. The evidence is most clear in patients with hypertension. Also remaining to be established is whether the treatment of sleep apnea prevents cardiac and vascular events. With regard to this question, although the available data strongly suggest that continuous positive airway pressure treatment is beneficial, randomized control trials are needed in order to confirm this. (Circ J 2009; 73: 1363 - 1370)
- 社団法人 日本循環器学会の論文
- 2009-07-20
著者
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Kato Masahiko
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Somers Virend
Divisions of Hypertension and Cardiovascular Disease, Mayo Clinic
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Somers Virend
Division Of Hypertension And Cardiovascular Disease Mayo Clinic
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Adachi Taro
Division Of Hypertension And Cardiovascular Disease Mayo Clinic
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KOSHINO Yuki
Division of Hypertension and Cardiovascular Disease, Mayo Clinic
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Koshino Yuki
Division Of Hypertension And Cardiovascular Disease Mayo Clinic
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Kato Masahiko
Department Of Allergy And Immunology Gunma Children's Medical Center
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KATO Masahiko
Department of Cardiovascular Medicine, Tottori University
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Adachi Taro
Division of Cardiology Department of Medicine, Showa University
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Somers Virend
Division of Cardiovascular Diseases, Mayo Clinic
関連論文
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