Usefulness of Rapid Low-Dose/High-Dose 1-Day ^<99m>Tc-Sestamibi ECG-Gated Myocardial Perfusion Single-Photon Emission Computed Tomography
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概要
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Background The clinical usefulness of a rapid rest low-dose/stress high-dose (dose ratio=1:5) ^<99m>Tc-sestamibi myocardial perfusion single-photon emission computed tomography (SPECT) protocol for the detection of coronary artery disease was evaluated. Methods and Results In 89 patients, rest images were obtained immediately after the injection of ^<99m>Tc-sestamibi (256.1±28.4MBq) followed by drinking water (400ml). Exercise or vasodilator stress test was performed immediately after the completion of rest imaging with the injection of ^<99m>Tc-sestamibi (1312.3±167.6 MBq). Prior to the post-stress imaging, patients were asked again to drink water (400ml) in order to eliminate subdiaphragmatic tracer activity. The myocardial count ratio (stress/rest) of ^<99m>Tc-sestamibi was calculated. Image quality was scored using a 4-point scale system (4=excellent, 3=good, 2=poor, 1=unacceptable). Coronary angiography was performed in 56 patients within 1 month of the SPECT scan. All patients successfully performed the protocol and total examination time was 108±7 min. The myocardial count ratio of ^<99m>Tc-sestamibi was always greater than 6. The image quality was satisfactory both at rest (3.4±0.9) and after stress (3.9±0.2). The sensitivity and specificity to detect coronary artery stenosis >50% was 84% and 97%, respectively. Conclusions This rapid one-day ^<99m>Tc-sestamibi protocol provides adequate image quality and diagnostic accuracy for detecting coronary artery disease.
- 2006-11-20
著者
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SUZUKI Yasuyuki
Department of Physics, Faculty of Science, Niigata University
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Matsumoto Naoya
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Sato Yuichi
Department of Imaging, Health Park Clinic Kurosawa
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Kato Masahiko
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
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Saito satoshi
Department of Medicine, Division of Cardiovascular Medicine, Nihon University School of Medicine
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Sato Sumiko
Ehime Prefectural Central Hospital
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Matsumoto Naoya
Department of Cardiology, Nihon University School of Medicine
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Yoda Shunichi
Department of Cardiology, Nihon University School of Medicine
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Kunimasa Taeko
Department of Cardiology, Nihon University School of Medicine
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Katoh Masahiko
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kofune Masayoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Matsumoto Naoya
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kunimasa Taeko
Department Of Cardiology Nihon University Surugadai Hospital
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Kato M
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Tadehara Futoshi
Department Of Cardiovascular Medicine Hiroshima University Hospital
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Sato Yuichi
Department Of Imaging Health Park Clinic Kurosawa
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Yoda Shunichi
Department Of Advanced Medicine Nihon University School Of Medicine
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Tadehara Futoshi
Kure Kyosai Hospital
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Lewin Howard
Cardiac Imaging Associates
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Hyun Mark
Cardiac Imaging Associates
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Matsumoto Naoya
Department Of Anatomy And Neurobiology Kyoto University Graduate School Of Medicine
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Kato Masahiko
Department Of Allergy And Immunology Gunma Children's Medical Center
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Suzuki Yasuyuki
Department Of Cardiology Nihon University Surugadai Hospital
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Yokoyama Shin-ichiro
Second Department Of Internal Medicine Nihon University School Of Medicine
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Kunimasa Taeko
Department Of Cardiology Nihon University School Of Medicine
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Komoriya Masakazu
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Saito Satoshi
Department Of Advanced Medical Science Nihon University School Of Medicine
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Sato Yoshiyuki
Department Of Cardiology Nihon Univeristy School Of Medicine
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Sato Yuichi
Department Of Applied Tumor Pathology Kitasato University Graduate School Of Medical Sciences
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Suzuki Yasuyuki
Department Of Biochemistry Kinki University School Of Medicine
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Sato Yuichi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Suzuki Yasuyuki
Department Of Anesthesia And Icu National Children's Hospital
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Matumoto Naoya
Department Of Cardiology Nihon University School Of Medicine
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Kunimasa Taeko
Division Of Cardiology Nihon University School Of Medicine
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Kunimasa Takeo
Department Of Cardiology Nihon University School Of Medicine
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