Effects of Long-Term Intravenous Administration of Adrenomedullin (AM) Plus hANP Therapy in Acute Decompensated Heart Failure : A Pilot Study
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概要
- 論文の詳細を見る
Background: It was reported previously that 30 min administration of adrenomedullin (AM) improves hemodynamics in chronic stable heart failure patients. The present study was designed to examine whether long-term AM + human atrial natriuretic peptide (hANP) administration can be used as a therapeutic drug in patients with acute decompensated heart failure (ADHF) in clinical setting. Methods and Results: Seven acute heart failure patients (74 ±5 years) with dyspnea and pulmonary congestion were studied. AM (0.02 μg · kg-1 · min-1) + hANP (0.05 μg · kg-1 · min-1) was infused for 12 h and then hANP (0.05 μg · kg-1 · min-1) was infused for 12 h. Hemodynamic, renal, hormonal and oxidative stress responses were evaluated. AM + hANP significantly reduced mean arterial pressure, pulmonary arterial pressure and systemic and pulmonary vascular resistance without changing heart rate, and increased cardiac output for most time-points compared with those at baseline. In addition, AM + hANP reduced aldosterone, brain natriuretic peptide and free-radical metabolites compared with those at baseline (all P<0.05). AM + hANP increased urine volume and UNaV compared with baseline data. Conclusions: In this small, pilot trial, AM + hANP therapy had beneficial hemodynamic and hormonal effects in ADHF. Intravenous infusion of AM with hANP could be used as a therapeutic drug in ADHF. These data are preliminary and require confirmation in a larger clinical study.
- 社団法人 日本循環器学会の論文
- 2009-04-20
著者
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Muratani H
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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NISHIKIMI Toshio
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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KARASAWA Tsuyoshi
Department of Intensive and Critical Care Medicine, Dokkyo Medical University, Mibu
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INABA Chikako
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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ISHIMURA Kimihiko
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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TADOKORO Kazuyoshi
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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KOSHIKAWA Shogo
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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YOSHIHARA Fumiki
Department of Medicine, National Cardiovascular Center
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NAGAYA Noritoshi
Research Institute National Cardiovascular Center
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SAKIO Hideaki
Department of Intensive and Critical Care Medicine, Dokkyo Medical University, Mibu
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KANGAWA Kenji
Research Institute National Cardiovascular Center
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MATSUOKA Hiroaki
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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Nishikimi Toshio
Yokohama Rosai Hospital
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Makino H
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine And Denti
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Matsuoka Hiroaki
大阪大学 医学系研究科老年･腎臓内科学
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Hori Masatsugu
大阪大学 大学院医学系研究科内科系臨床医学専攻核医学講座
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Matsubara Hiroaki
京都府立医科大学 循環器内科学
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Kitamura Kazuo
宮崎大学 医学部循環体液制御学
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Matsuo H
Department Of Internal Medicine Circulatory And Body Fluid Regulation Faculty Of Medicine University
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Sakio Hideaki
Department Of Intensive And Critical Care Medicine Dokkyo Medical University Mibu
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Yoshihara Fumiki
Division Of Hypertension And Nephrology National Cardiovascular Center
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Fujioka Yoshihiko
国立循環器病センター
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Yoshihara Fumiki
国立循環器病センター 高血圧腎臓内科
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Muratani Hiromi
琉球大学 第3内科
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Metoki Hirohito
東北大学 臨床薬学
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Kangawa K
Tokyo Medical University
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Kimura Kenjiro
東京大学 内科学
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Inaba Chikako
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University Mibu
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NISHIKAGE Tomoko
Acuson Nippon K.K.
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Nishimura T
Department Of Radiology Graduate School Of Medical Sciences Kyoto Prefectural University Of Medicine
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Nishimura Tsunehiko
大阪大学 トレーサ情報解析
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Muratani Hiromi
Geriatric Medicine Kanazawa Medical University
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Hori Masatsugu
Department Of Cardiology Osaka University Graduate School Of Medicine
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Maeba Hirofumi
Cardiovascular Center Kansai Medical University
-
Kitamura Kazuo
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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Horio M
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Pharmaceut
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Ishimura Kimihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University Mibu
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Kishimoto Ichirou
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Kitamura K
Faculty Of Medicine Department Of Internal Medicine Division Of Circulatory And Body Fluid Regulatio
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Mani Hiroki
Department Of Clinical Molecular Genetics And Laboratory Medicine Kyoto Prefectural University Of Me
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Kinugawa Koh-ichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Nishimura T
Department Of Radiology Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Nishimura Tsunehiko
Department Of Radiology Kyoto Prefectural University Of Medicine Graduate School Of Medical Science
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Matsuoka H
Kyoto Univ. Kyoto
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木村 晃二
国立循環器病センター 心臓血管
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Horio Masaru
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Nishikimi Toshio
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Matsuoka Hiroaki
Division Of Hypertension And Cardiorenal Disease Department Of Medicine Dokkyo University School Of
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Kitamura Kazuo
Division Of Circulatory And Body Fluid Regulation Faculty Of Medicine Department Of Internal Medicin
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Hori Masatsugu
Department Of Radiology National Center Hospital For Mental Nervous And Muscular Disorders National
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Maeba Hirofumi
Division Of Cardiology Kansai Medical University
-
Koshikawa Shogo
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University Mibu
-
Matsuda Hikaru
Department Of Cardiology Osaka University Graduate School Of Medicine
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Hori Masatsugu
Department Of Nephrology Osaka University Graduate School Of Medicine
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Nishimura Tsunehiko
Dept. Of Radiology And Artificial Organs National Cardiovascular Center
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Karasawa Tsuyoshi
Department Of Intensive And Critical Care Medicine Dokkyo Medical University Mibu
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Kubota Ken
Department Of Medicine Tokyo Metropolitan Komagome Hospital
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Horio Masaru
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine (a8)
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Nishimura Tunehiko
Department Radiology National Cardiovasucular Center
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Matsui Hiroshi
Research Institute National Center Of Cardiovascular Medicine
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Nagaya Noritoshi
Department Of Regenerative Medicine & Tissue Engineering National Cardiovascular Center Research
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
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Nishimura Tsunehiko
Radiology National Cardiovascular Center
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Kitamura K
Department Of Medicine Tokyo Metropolitan Komagome Hospital
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Kadota K
Department Of Internal Medicine Hyogo Hospital
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Mani Hiroki
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Kanagawa Kenji
Research Institute National Cardiovascular Center
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Matsuo Hisayuki
Research Institute National Center Of Cardiovascular Medicine
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Kanatsu Kazuro
The 3rd Division Department Of International Medicine Faculty Of Medicine
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Matsuoka Hiroaki
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Nagaya Noritoshi
Department Of Regenerative Medicine National Cardiovascular Center
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Komamura Kazuo
National Cardiovascular Center Division Of Cardiovascular Medicine
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Makino Hirofumi
International Medical Center Of Japan
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Higuchi Masayoshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
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Kamide Kei
Division Of Cardiovascular Medicine Department Of Medicine School Of Medicine Jichi Medical Universi
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Nagaya Noritoshi
Cardiovasclular Dynamics Dept National Cardiovascular Center
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
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Kuwasako Kenji
Research Institute National Cardiovascular Center
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Tadokoro Kazuyoshi
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University Mibu
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Reserch In
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Kangawa Kenji
Department Of Medicine And Geriatrics Osaka University Medical School:sakurabashi Watanabe Hospital
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Matsuoka Hiroaki
Department Of Bioscience National Cardiovascular Center Research Institute
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Kitamura Kazuo
First Department Of Internal Medicine Miyazaki Medical College
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Nishikimi Toshio
The Division Of Hypertension National Cardiovascular Center
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
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Hattori Motoshi
Department Of Pediatric Nephrology Tokyo Women's Medical University School Of Medicine
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I
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Nagaya Noritoshi
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Reserch Institute
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Nishikage Tomoko
Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of Medicine
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Nishikimi Toshio
Acuson Nippon K.k.
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- PJ-514 Adrenomedullin (AM) and Its Receptor Components (CRLR, RAMP2, and RAMP3) in Adipocytes : Its Role in Glucose Uptake and Lipolysis(Lipid disorders-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension
- -P243- The Problems in Evaluating Electrophysiological Characteristics of Accessory Pathway(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -P240- Changes of Atrial Refractoriness during Atrioventricular Reentrant Tachycardia in Patients with Wolff-Parkinson-White Syndrome:Relevance to Paroxysmal Atrial Fibrillation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
- -0645- Effects of disopyramide on th electrophysiological characteristics of the retrograde accessory pathway conduction in the standing position(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)