Amino Acids and Peptides. XXVIII. Preparation of Poly(Ethylene Glycol)Hybrids of Gln-Val-Val-Ala-Gly Analogs and Their Inhibitory Effect on Papain
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概要
- 論文の詳細を見る
Gln-Val-Val-Ala-Gly is a sequence which is common in cystetine protease inhibitors. Poly(ethylene glycol)hybrids of Gln-Val-Val-Ala-Gly analogs were prepared by the solid phase method by fluorenylmethyloxycarbonyl chemistry. The hybrid formation of Gln-Val-Val-Ala-Gly resulted in improvement of the solubility and also in enhancement of the inhibitory effect of the peptide on papain. In addition, the hybrid formation of Gln-Val-Val-Ala-Gly analogs resulted in the enhancement of the inhibitory effect of the peptide analogs.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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OKADA Yoshio
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Okada Yoshio
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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IGUCHI Shin
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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OKAMOTO Hiroshi
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Okamoto H
Faculty Of Pharmacy Meijo University
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INOUE Sachie
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Inoue Sachie
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Inoue S
Fujisawa Technical Serv. Co. Ltd. Osaka Jpn
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Okamoto Hiroshi
Faculty Of Engineering Chiba University
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IGUCHI Shin
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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