Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolysis System : Synthesis of Plasmin Inhibitor and Evaluation of Their Inhibitory Effect
スポンサーリンク
概要
- 論文の詳細を見る
- 1998-10-01
著者
-
TSUDA Yuko
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
OKADA Yoshio
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
Tsuda Yuko
Faculty Of Pharmaceutical Science Kobe Gakuin University
-
Okada Yoshio
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Okamoto Shosuke
Kobe Research Projects on Thrombosis and Haemostasis
-
Takahashi M
Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation
-
TADA Mayako
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
WANAKA Keiko
Kobe Research Projects on Thrombosis and Haemostasis
-
OKAMOTO Utako
Kobe Research Projects on Thrombosis and Haemostasis
-
HIJIKATA OKUNOMIYA
Faculty of Health Science, Kobe University School of Medicine
-
Hijikata Okunomiya
Faculty Of Health Science Kobe University School Of Medicine
-
Okamoto Shosuke
Kobe Research Projects On Thrombosis And Haemostatis
-
Wanaka Keiko
Kobe Research Projects On Thrombosis And Haemostatis
-
Tada M
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
TADA Mayako
Kobe Research Projects on Thrombosis and Haemostasis
-
KONISHI Yasuo
National Research Council Canada, Biotechnology Research Institute
-
Konishi Yasuo
National Research Council Canada Biotechnology Research Institute
-
Tsuda Y
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
-
岡本 成羽
Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.
関連論文
- Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
- Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
- Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
- Inhibiton of Thrombin-induced Cartilage Proteoglycan Release by Argatroban
- The Role of the Carboxyl Group of Asp_ of Bovine Pancreatic Ribonuclease A in Enzymatic Activity(Biological Chemistry)
- Amino Acids and Peptides. XLIV. Synthesis of Stereoisomeric Pentapeptides of Thiol Proteinase Inhibitor
- Cytotoxic Principles of a Bangladeshi Crude Drug, Akond Mul (Roots of Calotropis gigantea L.)
- Synthesis and Nematocidal Activity of Diarylnonanoids Related to Malabaricones
- Synthesis and Nematocidal Activity of Aralkyl- and Aralkenylamides Related to Piperamide on Second-Stage Larvae of Toxocara canis
- [2+2] Photocycloaddition Reaction of 5-Arylfuran-2,3-diones to Trimethylsilyloxyethylenes
- DNA Profiling of Acorus calamus Chemotypes Differing in Essential Oil Composition
- In Vitro Leishmanicidal Constituents of Millettia pendula
- Acacia concinna Saponins. II. Structures of Monoterpenoid Glycosides in the Alkaline Hydrolysate of the Saponin Fraction
- Acacia concinna Saponins. I. Structures of Prosapogenols, Concinnosides A-F, Isolated from the Alkaline Hydrolysate of the Highly Polar Saponin Fraction
- Amino Acids and Peptides. LV. Application of 2-Adamantyl Dericatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. II
- Amino Acids and Peptides. LIV. Application of 2-Adamantyl Derivatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. I
- Amino Acids and Peptides. LI. Application of the 2-Adamantyloxycarbonyl (2-Adoc) Group to the Protection of the Hydroxyl Function of Tyrosine in Peptide Synthesis
- Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration(Analytical Biochemistry)
- Fate of Orally Administered ^15N-LabeIed Polyamines in Rats Bearing Solid Tumors
- Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
- Deprotection of the Indole (N^)_Formyl (For) Group on Tryptophan Employing a New Reagent, N,N'-Dimethylethylendiamine (DMEDA) in an Aqueous Solution
- Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
- SYNTHESIS OF EGLIN C AND DEVELOPMENT OF INHIBITORS AGAINST HUMAN LEUKOCYTE ELASTASE AND CATHEPSIN G
- Synthesis of Peptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)(Organic,Chemical)
- Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
- Synthesis of Some Pseudo-Peptide Analogs of Thiol Proteinase Inhibitors
- In Vitro Screening of Leishmanicidal Activity in Myanmar Timber Extracts(Pharmacognosy)
- Detecting of Anaphylactic Reaction in the Percutaneously Sensitized Mouse Using the AW Method
- Suppression and Enhancement of the Freund's Incomplete Adjuvant-Induced Writhing Reaction by Sodium Ascorbate in Mice
- Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety : Confirmation of Stereostructure by X-Ray Analysis
- The Antiproliferative Activities of Somatostatin Analogs on Various Tumor Cells
- Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
- Studies on the Mechanism of 1,2-Dihydropyrazin-2-one Ring Formation from Dipeptidyl Chloromethyl Ketone and Its Chemical Properties : Immediate Deamination during Catalytic Hydrogenation
- Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
- Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
- Synthesis of Somatostatin Analogs and Their Antitumor Activities
- The Structure-Activity Relationship of Dmt-NH-X
- Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
- Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
- Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Their Activities
- Structure-Inhibitory Activity Relationship of Plasmin and Plasma Kallikrein Inhibitors^
- Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization
- Structure-Inhibitory Activity Relationships of Plasmin and Plasma Kallikrein Inhibitors
- Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule : X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin
- 26aYB-5 Exciton dynamics in Cd_Mn_xTe/ZnTe multiple quantum wells
- Evaluation of the Trifluoromethanosulfonic Acid/Trifluoroacetic Acid/Thioanisole Cleavage Procedure for Application in Solid-Phase Peptide Synthesis
- Resin Selection Based on the Lability of Peptidyl-Resin Linkage towards HF and TFA Steps : Dependence on the C-Terminal Amino Acid and Peptide Length
- Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
- Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
- Design and Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
- Synthesis of Endomorphin Analogs and Studies on the Structure-Opioid Receptor-Binding Activity Relationship
- Amino Acids and Peptides. LII. Design and Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Examinaiton of Their Opioid Receptor Binding Activity
- Synthesis of Pyrazinone Ring-Containing Tyrosine Derivatives and Examination of Their Binding Activity with Opioid Receptors
- Intradermal Delivery of Antisense Oligonucleotides by the Pulse Depolarization lontophoretic System(Biopharmacy)
- Synthesis and Antitumor Activity of Benzimidazolyl-1,3,5-triazine and Benzimidazolylpyrimidine Derivatives
- Synthesis and Aromatase-Inhibitory Activity of Imidazoly-1,3,5-triazine Derivatives
- Dioxopyrrolines.LXII. Diels-Alder Reaction of 1-Aryl-4-and 5-methoxycarbonyl-1H-pyrrole-2,3-diones with Various 1,3-Dienes
- Studies on the Stable Structure and Inhibitory Activity of Plasmin and Plasma Kallikrein Inhibitors Using the MM+ Force Field
- Synthesis of Cyclic Peptides with Agonist Activity for Melanocortin Receptors
- Synthesis of Glycosylcurcuminoids
- SYNTHESIS OF ω-TERT-BUTYL ESTERS OF ASPARTIC ACID AND GLUTAMIC ACID VIA B, B-DIFLUOROBOROXAZOLIDONES
- Application of Amino Acid Boron Complexes to Introduction of Side Chain Protecting Groups
- Amino Acids and Peptides. XXVIII. Preparation of Poly(Ethylene Glycol)Hybrids of Gln-Val-Val-Ala-Gly Analogs and Their Inhibitory Effect on Papain
- Synthesis of γ-2-Adamantylglutamate and Its Application to the Peptide Synthesis
- Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship
- Development of Plasmin Inhibitors and Their Effect on M1(Melanoma) and HT29 Cell Lines
- Preparation of Highly Efficient Resin for Affinity Chromatography Employing Synthetic Specific Inhibitors : Further Studies on Purification of Plasma Kallikrein (PK)
- Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship
- Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527,a Plasma Kallikrein Selective Inhibitor : The Importance of the Peptide Backbone
- Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolysis System : Synthesis of Plasmin Inhibitor and Evaluation of Their Inhibitory Effect
- Design of Plasma Kallikrein Inhibitors : Functional and Structural Requirements of Plasma Kallikrein Inhibitors
- Purification Method for Human Plasma Kallikrein by a New Affinity Chromatography
- Purification of Plasma Kallikrein (PK) : Preparation of PK Specific Inhibitor-Polymer Conjugate and Its Application to Purification of PK
- Design of Plasma Kallikrein Inhibitors
- Synthesis of 2(1H)-Pyrazinone Derivatives from Dipeptides and Its Application to the Development of Proteinase Inhibitor
- DEVELOPMENT OF A PLASMA KALLIKREIN SELECTIVE INHIBITOR
- Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
- Studies toward Total Synthesis of Non-Aromatic Erythrinan Alkaloids. 7. Synthesis of Cocculolidine Skeleton
- The Structure-Activity Relationship of [Dmt^1]Endomorphin-2 Derivatives
- The Structure-Activity Relationship of the Opioidmimetics Containing 2(1H)-Pyrazinone Ring as a Linker and Observation of Deamination during Synthesis
- Design of Opioidmimetics : Dimerization of 2', 6'-Dimethyl-L-Tyrosine
- Degradation of a Novel Tripeptide, tert-Butoxycarbonyl-Tyr-Leu-Val-CH_2Cl, with Inhibitory Effect on Human Leukocyte Elastase in Aqueous Solution and in Biological Fluids
- Structure-Activity Relationship between Arginine Derivatives and Inhibitory Activity of Horse Serum Cholinesterase
- Amino Acids and Peptides. L. Development of a Novel N^π-Protecting Group for Histidine, N^π-2-Adamantyloxymethylhistidine, and Its Application to peptide Synthesis
- DEVELOPMENT OF A NEW N^π-PROTECTING GROUP FOR HISTIDINE, N^π-1-ADAMANTYLOXYMETHYLSHISTIDINE
- Synthesis and Properties of N(π)-1- and 2-Adamantyl-oxymethylhistidines, His[N(π)-1- and 2-Adom]
- Amino Acids and Peptides. XLVII. Facile Synthesis of Flavacol, Deoxymuta-aspergillic Acid and Optically Active Deoxyaspergillic Acid from Dipeptidyl Aldehydes
- Amino Acids and Peptides. XLVI. Introduction of Carboxyl Function into Pyrazinone by Using Newly Developed Procedure for pyrazinone Ring Formation : Observation of Immediate Decarboxylation
- Effect of YO-2 (Plasmin Inhibitor) on the Growth of Human Tumor Xenografts in Mice
- VALENCE-SHELL ELECTRON MOMENTUM DISTRIBUTIONS AND IONIZATION ENERGY SPECTRA OF FURAN BY (e, 2e) SPECTROSCOPY
- A Class of Novel Plasmin Inhibitors
- Relationship between structure and P-glycoprotein inhibitory activity of dimeric opioid peptides containing the Dmt-Tic pharmacophore
- Amino Acids and Peptides. XLIX. Synthesis of γ-2-Adamantylglutamate and Its Evaluation for Peptide Synthesis
- The Considerable Effects on Anti-tumor Activity and Cell Permeability of Small Peptides Containing Adamantyl Group
- Comparative Investigation of the Cleavage Step in the Synthesis of Model Peptide Resins : Implications for N^α-9-Fluorenylmethyloxycarbonyl-Solid Phase Peptide Synthesis
- Design and Synthesis of Conformational Freedom Restricted Endomorphin-2 Analogues
- Hydrophobic Interaction between Plasmin Inhibitors and the S1' Site
- Oxamide Replacement in Pseudo-Symmetric HIV Protease Inhibitor Involving Multiple Bridging Water Molecules
- Inhibitory Effect of Peptide Mimetics Including Naphthyl Group on DNA Polymerase β Activity
- Synthesis and Anticancer Activities of Lipophyllic Somatostatin Derivatives