Suppression and Enhancement of the Freund's Incomplete Adjuvant-Induced Writhing Reaction by Sodium Ascorbate in Mice

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概要

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• We noticed that an intraperitoneal injection of Freund's incomplete adjuvant (FIA) into mice could stimulate the induction of a writhing reaction. The FIA emulsion-induced writhing reaction was found to be remarkably inhibited by preadministration of oral indomethacin, a non-steroidal anti-inflammatory and analgesic drug. The induction of the writhing reaction was also inhibited by intravenous preadministration of sodium ascorbate (SAs) in saline. In the experiments where SAs was added to FIA, t was demonstrated that SAs had dual activity of suppression and enhancement. At lower concentrations SAs functioned as a suppressor of the writhing reaction, while at concentrations higher than about 1 mg/50 μl/mouse it acted as an enhancer of the reaction. Furthermore, this writhing reaction induced by FIA+Sas emulsion was also inhibited by preadministraion of SAs itself as well as indomethacin. These results suggested that the mechanism of the erithing reaction induced by FIA was concerned with the production of prostaglandins (PGs), and SAs might be involved in regulation of the writhing reaction.In this paper, we propose a mouse writhing model induced by FIA or FIA+SAs emulsion as a novel pain model useful for assessment of analgesic and anti-inflammatory agents.

• 公益社団法人日本薬学会の論文
• 1999-02-15

著者

• 伊藤 裕二

  Department Of Pharmaceutics Research Center Taisho Pharmaceutical Co. Ltd.

• Semma Masanori

  School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University

• Semma Masanori

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Yokoi T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Ito Yoshihisa

  College Of Pharmacy Nihon University

• Kataoka Hiromi

  School Of Pharmaceutical Sciences Mukogawa Women 's University

• KATAOKA Hiromi

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Ito Yoshihisa

  Res. Unit Of Pharmacology Dep. Of Clinical Pharmacy School Of Pharmacy Nihon Univ. Jpn

• SHINOHARA Yuki

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• TAKATANI Tomoka

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• MIZUTA Akane

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• TSUDA Yoshimi

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• FUKUI Hisae

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• ITO Yoshio

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• IMA Michiko

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Fukui Hisae

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Ima Michiko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Mizuta Akane

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Shinohara Yuki

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Takatani Tomoka

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Ito Y

  Nihon Univ. Funabashi Jpn

• Ito Yuji

  Otc Product R & D Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Ito Yoshio

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• SEMMA Masanori

  Faculty of Pharmaceutical Science, Mukogawa Women's University

• ITO Yoshio

  Faculty of Pharmaceutical Science, Mukogawa Women's University

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