The Structure-Activity Relationship of the Opioidmimetics Containing 2(1H)-Pyrazinone Ring as a Linker and Observation of Deamination during Synthesis

スポンサーリンク

概要

• 論文の詳細を見る
• 2003-02-01

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• MIYAZAKI Anna

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• AMBO Akihiro

  Tohoku Pharmaceutical University

• SASAKI Yusuke

  Tohoku Pharmaceutical University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Miyazaki Anna

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Sasaki Y

  Tohoku Pharmaceutical University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• YOKOI Toshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• BRYANT Sharon

  Peptide Neurochemistry, LCBRA, National Institute of Environmental Health Sciences, Research Triangl

• LAZARUS Lawrence

  Peptide Neurochemistry, LCBRA, National Institute of Environmental Health Sciences, Research Triangl

• LI Tingyou

  High technology Research Center, Kobe Gakuin University

• FUJISAWA Yutaka

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• SHIOTANI Kimitaka

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• FUJITA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• MORISHITA Akihisa

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Li Tingyou

  High Technology Research Center Kobe Gakuin University

• Yokoi Toshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Fujisawa Yutaka

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Fujita Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Lazarus Lawrence

  Peptide Neurochemistry Lcbra National Institute Of Environmental Health Sciences Research Triangle P

• Bryant Sharon

  Peptide Neurochemistry Lcbra National Institute Of Environmental Health Sciences Research Triangle P

• Yokoi Toshio

  Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University

• Shiotani Kimitaka

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Morishita Akihisa

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Sasaki Yusuke

  Tohoku College Of Pharmacy

関連論文

• Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
• Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
• Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
• The Role of the Carboxyl Group of Asp_ of Bovine Pancreatic Ribonuclease A in Enzymatic Activity(Biological Chemistry)
• Sequence Analysis of Chinese and Japanese Curcuma Drugs on the 18S rRNA Gene and trnK Gene and the Application of Amplification-Refractory Mutation System Analysis for Their Authentication
• Molecular Analysis of Medicinally-Used Chinese and Japanese Curcuma Based on 18S rRNA Gene and trnK Gene Sequences
• Amino Acids and Peptides. XLIV. Synthesis of Stereoisomeric Pentapeptides of Thiol Proteinase Inhibitor
• Synthesis and Nematocidal Activity of Diarylnonanoids Related to Malabaricones
• DNA Profiling of Acorus calamus Chemotypes Differing in Essential Oil Composition
• Amino Acids and Peptides. LV. Application of 2-Adamantyl Dericatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. II
• Amino Acids and Peptides. LIV. Application of 2-Adamantyl Derivatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. I
• Amino Acids and Peptides. LI. Application of the 2-Adamantyloxycarbonyl (2-Adoc) Group to the Protection of the Hydroxyl Function of Tyrosine in Peptide Synthesis
• Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
• Deprotection of the Indole (N^)_Formyl (For) Group on Tryptophan Employing a New Reagent, N,N'-Dimethylethylendiamine (DMEDA) in an Aqueous Solution
• Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
• SYNTHESIS OF EGLIN C AND DEVELOPMENT OF INHIBITORS AGAINST HUMAN LEUKOCYTE ELASTASE AND CATHEPSIN G
• Synthesis of Peptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)(Organic,Chemical)
• Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
• Synthesis and Biological Activity of Opioid Peptides Replaced Phenylalanine at Position 3 or 4 by 2, 6-Dimethylphenylalanine
• Biological Properties of Opioid Peptides Replacing Tyr at Position 1 by 2,6-Dimethyl-Tyr
• Synthesis of Some Pseudo-Peptide Analogs of Thiol Proteinase Inhibitors
• Morphological, genetic, and chemical polymorphism of Curcuma kwangsiensis
• Application of Single-Nucleotide Polymorphism Analysis of the trnK Gene to the Identification of Curcuma Plants
• Detecting of Anaphylactic Reaction in the Percutaneously Sensitized Mouse Using the AW Method
• Suppression and Enhancement of the Freund's Incomplete Adjuvant-Induced Writhing Reaction by Sodium Ascorbate in Mice
• Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety : Confirmation of Stereostructure by X-Ray Analysis
• The Antiproliferative Activities of Somatostatin Analogs on Various Tumor Cells
• Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
• Studies on the Mechanism of 1,2-Dihydropyrazin-2-one Ring Formation from Dipeptidyl Chloromethyl Ketone and Its Chemical Properties : Immediate Deamination during Catalytic Hydrogenation
• Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
• Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
• Synthesis of Somatostatin Analogs and Their Antitumor Activities
• The Structure-Activity Relationship of Dmt-NH-X
• Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
• Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
• Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Their Activities
• Structure-Inhibitory Activity Relationship of Plasmin and Plasma Kallikrein Inhibitors^
• Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization
• Structure-Inhibitory Activity Relationships of Plasmin and Plasma Kallikrein Inhibitors
• Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule : X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin
• Evaluation of the Trifluoromethanosulfonic Acid/Trifluoroacetic Acid/Thioanisole Cleavage Procedure for Application in Solid-Phase Peptide Synthesis
• Resin Selection Based on the Lability of Peptidyl-Resin Linkage towards HF and TFA Steps : Dependence on the C-Terminal Amino Acid and Peptide Length
• Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
• Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
• Design and Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
• Synthesis of Endomorphin Analogs and Studies on the Structure-Opioid Receptor-Binding Activity Relationship
• Amino Acids and Peptides. LII. Design and Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Examinaiton of Their Opioid Receptor Binding Activity
• Synthesis of Pyrazinone Ring-Containing Tyrosine Derivatives and Examination of Their Binding Activity with Opioid Receptors
• Dioxopyrrolines.LXII. Diels-Alder Reaction of 1-Aryl-4-and 5-methoxycarbonyl-1H-pyrrole-2,3-diones with Various 1,3-Dienes
• Studies on the Stable Structure and Inhibitory Activity of Plasmin and Plasma Kallikrein Inhibitors Using the MM+ Force Field
• Synthesis of Cyclic Peptides with Agonist Activity for Melanocortin Receptors
• Synthesis of Glycosylcurcuminoids
• Receptor Binding Properties and Antinociceptive Effects of Chimeric Peptides Consisting of a μ-Opioid Receptor Agonist and an ORL1 Receptor Antagonist(Medicinal Chemistry)
• SYNTHESIS OF ω-TERT-BUTYL ESTERS OF ASPARTIC ACID AND GLUTAMIC ACID VIA B, B-DIFLUOROBOROXAZOLIDONES
• Application of Amino Acid Boron Complexes to Introduction of Side Chain Protecting Groups
• Amino Acids and Peptides. XXVIII. Preparation of Poly(Ethylene Glycol)Hybrids of Gln-Val-Val-Ala-Gly Analogs and Their Inhibitory Effect on Papain
• Synthesis of γ-2-Adamantylglutamate and Its Application to the Peptide Synthesis
• Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship
• Development of Plasmin Inhibitors and Their Effect on M1(Melanoma) and HT29 Cell Lines
• Preparation of Highly Efficient Resin for Affinity Chromatography Employing Synthetic Specific Inhibitors : Further Studies on Purification of Plasma Kallikrein (PK)
• Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship
• Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527,a Plasma Kallikrein Selective Inhibitor : The Importance of the Peptide Backbone
• Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolysis System : Synthesis of Plasmin Inhibitor and Evaluation of Their Inhibitory Effect
• Design of Plasma Kallikrein Inhibitors : Functional and Structural Requirements of Plasma Kallikrein Inhibitors
• Purification Method for Human Plasma Kallikrein by a New Affinity Chromatography
• Purification of Plasma Kallikrein (PK) : Preparation of PK Specific Inhibitor-Polymer Conjugate and Its Application to Purification of PK
• Design of Plasma Kallikrein Inhibitors
• Synthesis of 2(1H)-Pyrazinone Derivatives from Dipeptides and Its Application to the Development of Proteinase Inhibitor
• DEVELOPMENT OF A PLASMA KALLIKREIN SELECTIVE INHIBITOR
• Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
• Studies toward Total Synthesis of Non-Aromatic Erythrinan Alkaloids. 7. Synthesis of Cocculolidine Skeleton
• The Structure-Activity Relationship of [Dmt^1]Endomorphin-2 Derivatives
• The Structure-Activity Relationship of the Opioidmimetics Containing 2(1H)-Pyrazinone Ring as a Linker and Observation of Deamination during Synthesis
• Design of Opioidmimetics : Dimerization of 2', 6'-Dimethyl-L-Tyrosine
• Degradation of a Novel Tripeptide, tert-Butoxycarbonyl-Tyr-Leu-Val-CH_2Cl, with Inhibitory Effect on Human Leukocyte Elastase in Aqueous Solution and in Biological Fluids
• Nociceptin and Dynorphin A Analogues with Dmp Substituted for N-Terminal Aromatic Residues
• 2',6'-Dimethylphenylalanine (Dmp) Can Mimic the N-Terminal Tyr in Opioid Peptides(Medicinal Chemistry)
• Biological Activity of Dermorphin and Deltorphin-II Analogs Replaced Phenylalanine at Position 3 by 2,6-Dimethylphenylalanine
• Structure-Activity Relationship between Arginine Derivatives and Inhibitory Activity of Horse Serum Cholinesterase
• Amino Acids and Peptides. L. Development of a Novel N^π-Protecting Group for Histidine, N^π-2-Adamantyloxymethylhistidine, and Its Application to peptide Synthesis
• DEVELOPMENT OF A NEW N^π-PROTECTING GROUP FOR HISTIDINE, N^π-1-ADAMANTYLOXYMETHYLSHISTIDINE
• Synthesis and Properties of N(π)-1- and 2-Adamantyl-oxymethylhistidines, His[N(π)-1- and 2-Adom]
• Amino Acids and Peptides. XLVII. Facile Synthesis of Flavacol, Deoxymuta-aspergillic Acid and Optically Active Deoxyaspergillic Acid from Dipeptidyl Aldehydes
• Amino Acids and Peptides. XLVI. Introduction of Carboxyl Function into Pyrazinone by Using Newly Developed Procedure for pyrazinone Ring Formation : Observation of Immediate Decarboxylation
• Effect of YO-2 (Plasmin Inhibitor) on the Growth of Human Tumor Xenografts in Mice
• Solid Phase Synthesis of ψCH_2NH Pseudo-Peptide Analogs Using 2, 4-Dimethoxybenzyl Group as the Pseudobond Protecting Group
• Identification of a Novel Carbohydrate-Mimicking Octapeptide from Chemical Peptide Library and Characterization as Selectin Inhibitor
• A Class of Novel Plasmin Inhibitors
• Protection of ψ(CH_2NH) Peptide Bond with 2,4-Dimethoxybenzyl Group in Solid-Phase Peptide Synthesis
• Relationship between structure and P-glycoprotein inhibitory activity of dimeric opioid peptides containing the Dmt-Tic pharmacophore
• Amino Acids and Peptides. XLIX. Synthesis of γ-2-Adamantylglutamate and Its Evaluation for Peptide Synthesis
• The Considerable Effects on Anti-tumor Activity and Cell Permeability of Small Peptides Containing Adamantyl Group
• Receptor Affinity and Selectivity of Dermorphin-Related Analogs Containing 2', 6'-Dimethylphenylalanine in Position 1 or 3
• Synthesis of Bivalent Ac-RYYRIK-NH_2 Analogues and the Optimal Spacer Length for ORL1 Receptor Binding
• Novel [_D-Arg^2]dermorphin(1-4) Analogs with μ-Opioid Receptor Antagonist Activity
• Design and Synthesis of Conformational Freedom Restricted Endomorphin-2 Analogues
• Hydrophobic Interaction between Plasmin Inhibitors and the S1' Site
• Oxamide Replacement in Pseudo-Symmetric HIV Protease Inhibitor Involving Multiple Bridging Water Molecules
• Inhibitory Effect of Peptide Mimetics Including Naphthyl Group on DNA Polymerase β Activity
• Synthesis and Anticancer Activities of Lipophyllic Somatostatin Derivatives

もっと見る 閉じる

スポンサーリンク