Amino Acids and Peptides. XLIV. Synthesis of Stereoisomeric Pentapeptides of Thiol Proteinase Inhibitor

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概要

• 論文の詳細を見る

• Stereoisomers of thiol proteinase inhibitor (TPI) were synthesized by a conventional solution method. Among them, iNoc-D-Gln-Val-Ala-Ala-pNA weakly inhibited the aminolytic activity of papain, although iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited papain activity fairly potently. However, the other five D-amino acid-containing peptides did not show any inhibitor effects on papain. The circular dichroism (CD) spectra of the enzyme-peptides mixtures were measured in order to study the relationship between the peptide anilides-papain interaction and the inhibitory activity.

• 公益社団法人日本薬学会の論文
• 1996-08-15

著者

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Hirano K

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Okamoto H

  Department Of Systems Innovation Graduate School Of Engineering Science Osaka University

• Okamoto H

  Ntt Optoelectronics Kanagawa Jpn

• IGUCHI Shin

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• HIRANO Kenichi

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKAMOTO Hiroshi

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKAMOTO Yoshiko

  Dai-ichi College of Pharmaceutical Science

• Okamoto H

  Faculty Of Pharmacy Meijo University

• Okamaoto H

  Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive

• Okamoto H

  Department Of Systems And Control Engineering Anan National College Of Technology

• Hirano Kenichi

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 岡本 宏巳

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Inoue S

  Fujisawa Technical Serv. Co. Ltd. Osaka Jpn

• Okamoto Hiroshi

  Faculty Of Engineering Chiba University

• Okamoto Hiroshi

  Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive

• IGUCHI Shin

  Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

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