Structure-Inhibitory Activity Relationship of Plasmin and Plasma Kallikrein Inhibitors^<1)>

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概要

• 論文の詳細を見る

• Based on the structure of Tra-Try(O-Pic)-octylamide, a portion of the octylamine was replaced with moieties bearing hydrophobic, basic or acidic groups. Replacement of the C-terminal residue with a moiety bearing a hydrophobic group gave the proper affinity of the inhibitor to both plasmin (PL) and plasma kallikrein (PK). While addition of a basic residue did not improve the affinity of the inhibitor, a carboxylic acid attached to the phenyl ring increased the PK selectivity of the inhibitor.

• 公益社団法人日本薬学会の論文
• 2001-11-01

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Yokoi T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:cooperative Research Center Of Life Scienc

• Tsuda Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Hijikata-Okunomiya Akiko

  Faculty of Health Science, Kobe University School of Medicine

• Okamoto Shosuke

  Kobe Research Projects on Thrombosis and Haemostasis

• Takahashi M

  Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation

• TADA Mayako

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• WANAKA Keiko

  Kobe Research Projects on Thrombosis and Haemostasis

• OKAMOTO Utako

  Kobe Research Projects on Thrombosis and Haemostasis

• Hijikata‐okunomiya A

  Faculty Of Health Science Kobe University School Of Medicine

• Hijikata-okunomiya Akiko

  Faculty Of Health Science Kobe University School Of Medicine

• Okamoto Shosuke

  Kobe Research Projects On Thrombosis And Haemostatis

• Wanaka Keiko

  Kobe Research Projects On Thrombosis And Haemostatis

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tada M

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• 岡本 成羽

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

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