Synthesis and Aromatase-Inhibitory Activity of Imidazoly-1,3,5-triazine Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Triamino-substituted 1,3,5-triazine derivatives were synthesized and tested for inhibitory activities against the aromatase of human lacental microsomes and the cytochrome P450 side chain cleavage of cholesterol (P450_<SCC>) of pig adrenal mitochondria. The compounds having imidazolyl and tertiary amino groups as substituents in the 1,3,5-triazine ring showed significant aromatase-inhibitory activity. Among them, compounds 17,23,26,27 and 28 were more active than the reference compound, CGS 16949A. The inhibitory activities of these compounds against P450_<SCC> were much weaker than their aromatase-inhibitory activities. These compounds may be regarded as selective aromatase inhibitors.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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MATSUNO Toshiyuki
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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Takahashi M
Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation
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Matsuno Toshiyuki
Research Laboratory Zenyaku Kogyo Co. Ltd.
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KATO Masanobu
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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TAKAHASHI Masayuki
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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YAGUCHI Shin-ichi
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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TSUCHIDA Yoshio
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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YAGUCHI Sin-ichi
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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TERADA Sumio
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Terada S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Tsuchida Y
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Tsuchida Yoshio
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Matsuno T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Matsuno T
Kyoto Pharmaceutical University
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Yaguchi S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Tsukatani Masaki
Faculty Of Pharmaceutical Science Kobe Gakuin University
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