生薬のEpstein-Barr Virus活性化抑制作用および抗発癌プロモーター作用について(第1報)
スポンサーリンク
概要
- 論文の詳細を見る
Methanol extracts of Myrobalan (1), knots of Wisteria brachybotrys (2), fruits of Trapa japonica (3) and Coix seed (4) were assayed for their inhibitory effects on Epstein-Barr virus (EBV) activations by a short term in vitro assay in which lymphoblastoid cells (Raji) latently infected with EBV were used. The EBV activation by 12-0-tetradecanoylphorbol-13-acetate (TPA) and teleocidin B was inhibited markedly by 1 and 2 but only weakly by 3. Coix seed (4) was found to show a significant in vitro cytotoxic effect on the Raji cells. The methanolic extracts from four mixtures of the crude drugs i.e., 1 and 4, 2 and 3, 2 and 4, and 2, 3 and 4, gave more enhanced inhibitory effects on EBV activation, with less cytotoxicity. These inhibitory effects on EBV activation suggested that these crude drugs possess antitumor promoting activities.
- 日本生薬学会の論文
- 1987-12-20
著者
-
徳田 春邦
京都府立医科大学生化学教室
-
小塚 睦夫
京都薬科大学
-
木島 孝夫
京都薬科大学
-
徳田 春邦
京都大学医学部
-
田部 昌弘
長倉製薬株式会社
-
Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
-
岡本 えみ子
京都薬科大学
関連論文
- 127(P-70) トリコテシノール類の発がんプロモーター活性と合成研究(ポスター発表の部)
- 1. マウス紫外線皮膚発がんモデルにおけるα-tocopherol摂取による発がん抑制の検討
- P090 ヤマブドウ(Vitis coignetiae)成分によるヒト由来細胞における多環芳香族アミン誘導小核の形成抑制(ポスターセッション)
- 3. 遅発性骨格筋損傷とビタミンE
- Acid-Base Behavior of Substituted Hydrazone Complexes Controlled by the Coordination Geometry
- 28D-09 イヌトウキおよびアガリクス茸の肝腫瘍発生抑制に関する検討
- 30C-01 カワリハラ茸及びイヌトウキの発癌プロモーター抑制作用
- 2-I-12 マウス肺二段階発癌系におけるα-カロチン及びβ-カロチンの体内動向について : 第45回大会研究発表要旨
- Studies no Inhibitors of Skin Tumor Promotion. XI. Inhibitory Effects of Flavonoids from Scutellaria baicalensis on Epstein-Barr Virus Activation and Their Anti-tumor-Promoting Activities
- Isolation and Identification of Anti-tumor-Promoting Principles from the Fresh-Water Cyanobacterium Phormidium tenue
- ^C Nuclear Magnetic Resonance Spectral Studies on Gleditsia Saponin C (GS-C)
- 防已科植物アルカロイド研究(第223報) : Stephania rotunda LOUREIROのアルカロイド(補遺その1)
- The Suppressive Effect of Mangiferin with Exercise on Blood Lipids in Type 2 Diabetes
- Hypolipidemic activity of Mangiferin in cholesterol-fed mice
- New Antidiabetic Compounds, Mangiferin and Its Glucoside
- Phytochemical Studies on Meliaceous Plants. VIII. Structures and Inhibitory Effects on Epstein-Barr Virus Activation of Triterpenoids from Leaves of Chisocheton macrophyllus KING
- 漢方方剤の抗発癌プロモーター作用(第2報)小青龍湯によるマウス皮膚及び肺発癌プロモーター抑制効果
- Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice(Pharmacognosy)
- Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice
- Hypoglycemic Activity of the Fruit of the Momordica charantia in Type 2 Diabetic Mice
- Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside
- Effect of Alpha-Linolenic Acid on Blood Glucose, Insulin and GLUT4 Protein Content of Type 2 Diabetic Mice
- Effect of Epinephrine of GLUT2 Protein Content in Mouse Liver
- New 5-HT_3 (Serotonin-3) Receptor Antagonists. V. Synthesis and Structure-Activity Relationships of Pyrrolo[2,1-c][1,4]benzoxazine-6-carboxamides
- New 5-HT_3 (Serotonin-3) Receptor Antagonists. IV. Synthesis and Structure-Activity Relationships of Azabicycloalkaneacetamide Derivatives
- New 5-HT_3 (Serotonin-3) Receptor Antagonists. III. An Efficient Synthesis of Carbon 14-Labeled (+)-8,9-Dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one Hydrochloride (FK 1052)
- Anti-tumor Promoting Activities of Natural Products. II. Inhibitory Effects of Digitoxin on Two-Stage Carcinogenesis of Mouse Skin Tumors and Mouse Pulmonary Tumors
- テルペノイドによるがん予防
- Structural Elucidation and Chemical Conversion of Amorphispironone, a Novel Spironone form Amorpha fruticosa, to Rotenoids
- D-aspartate oxidase activity and d-aspartate content of the senescence-accelerated mouse
- 植物細胞培養による紫外線障害抑制物質の探索研究[1] : 食品
- ビタミンB_2誘導体の発癌抑制作用 : ビタミン・バイオファクターの新機能の発掘
- BIOACTIVITY OF NICKEL (II) COMPLEX CONTAINING N-GLYCOSIDES DERIVED FROM D-GLUCOSAMINE AND ETHYLENEDIAMINE AGAINST PATHOGENIC YEAST, CANDIDA ALBICANS
- Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumors
- マツグミTaxillus kaempferi及び宿主クロマツPinus thunbergiiの成分(第1報)マツグミのカテキン類とフラボン類について
- Trachelogenin Methyl Ether から Epitrachelogenin Methyl Ether への誘導
- Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumor. II
- EFFECT OF SENEGIN-II ON BLOOD GLUCOSE IN NORMAL AND NIDDM MICE
- Hypoglycemic Effect of the Rhizomes of Ophiopogonis Tuber in Normal and Diabetic Mice
- Inhibitors of Skin-Tumor Promotion. VIII. : Inhibitory Effects of Euglobals and Their Related Compounds on Epstein-Barr Virus Activation. (1)
- フモニシンB1の標的の一つとしてのプロテインホスファターゼ
- 天然食用色素の抗がん作用 (特集 食品成分とがん予防)
- 27 新規発ガンプロモーター、trichothecinol A(口頭発表の部)
- ポリハイドロキシアミノ化合物の発癌プロモーター活性について
- Anti-Tumor-Promoting Activities of Euglobals from Eucalyptus Plants
- Inhibitors of Skin-Tumor Promotion. XIII. Inhibitory Effects of Euglobals and Their Related Compounds on Epstein-Barr Virus Activation and on Two-Stage Carcinogenesis of Mouse Skin Tumors. (2)
- Inhibitory Effect of Natural Carotenoids on Epstein-Barr Virus Activation Activity of a Tumor Promoter in Raji Cells. A Screening Study for Anti-tumor Promoters
- 9.D-アスパラギン酸酸化酵素活性に影響を及ぼす生理的諸条件 : ビタミンB研究委員会第325回会議研究発表要旨
- 2-I-19老化促進モデルマウスにおけるルD-アスパラギン酸酸化酵素活性とD-アスパラギン酸含量 : 第43回大会研究発表要旨
- テンダイウヤクLindera strychnifolia(SIEB.et ZUCC.)F.VILL.およびクロモジLindera umbellata THUNB.のアルカロイド
- 防巳科植物アルカロイド研究(第245報) : タマサキツヅラフジStephania cepharantha HAYATAのアルカロイドその7 Cepharamineの構造
- モクレン科植物アルカロイド研究(第38報) : タイサンボク Magnolia grandiflora LINN. のアルカロイド その 4
- 防已科植物アルカロイド研究(第235報) : Cyclea barbata(WALL.)MIERSのアルカロイド
- P-42 Eucalyptus属植物に含まれるeuglobal類の構造研究(ポスター発表の部)
- STRUCTURES OF EUGLOBAL-G1,-G2,AND -G3 FROM EUCALYPTUS GRANDIS, THREE NEW INHIBITORS OF EPSTEIN- BARR VIRUS ACTIVATION
- 生薬製剤, 紫雲膏のEpstein-Barr Virus活性化抑制作用と抗発癌プロモーター作用
- Studies on the Constituents of Leguminous Plants. XII. : The Structures of New Triterpenoid Saponins from Wistaria branchybotrys SIEB. et ZUCC.
- Antidiabetic Mechanism of Bakumondo-inshi
- EFFECT OF GINSENG RADIX ON GLUT2 PROTEIN CONTENT IN MOUSE LIVER IN NORMAL AND EPINEPHRINE-INDUCED HYPERGLYCEMIC MICE
- Determination of Hemoglobin A_ in Normal and Diabetic Mice : Neonatal Streptozotocin-Induced Diabetic Mice and KK-Ay Mice
- Intraperitoneal Administration of Senegae Radix Extract and Its Main Component, Senegin-II, Affects Lipid Metabolism in Normal and Hyperlipidemic Mice
- Studies on the Constituents of Leguminous Plants. XI. : The Structures of New Triterpenoids from Wistaria brachybotrys SIEB. et ZUCC.
- 国際天然物研究会議
- Aporphine Alkaloids from Parabenzoin praecox (SIEB. et ZUCC.) NAKAI
- 防已科植物アルカロイド研究(第251報) : タマサキツヅラフジStephania cepharantha HAYATAのアルカロイドその8 : 日本栽培種タマサキツヅラフジのアルカロイド
- 防巳科植物アルカロイド研究(第229報) : シマハスノハカズラStephania tetrandra S.MOORE のアルカロイド 補遺その1
- 防巳科植物アルカロイド研究(第228報) : ホウライツヅラフジPericampylus formosanus DIELSのアルカロイド
- 防巳科植物アルカロイド研究(第227報) : Stephania rotunda LOUREIROのアルカロイド(補遺その2)
- Studies on the Constituents of Leguminous Plants. VIII. The Structure of a New Triterpenoid Saponin from the Fruits of Gymnocladus chinensis BAILLON
- Studies on the Constituents of Leguminous Plants. VII. The Structure of Triterpenoid Saponins from Fruits of Gymnocladus chinensis BAILLON
- Legume Saponins of Gleditsia japonica MIQUEL. V. ^C Nuclear Magnetic Resonance Spectral Studies on the Structures of Gleditsia Saponins D_2,G and I
- Legume Saponins of Gleditsia japonica MIQUEL. IV. ^C-Nuclear Magnetic Resonance Spectral Studies for Structure Elucidation of Gleditsia Saponins B and C
- Legume Saponins of Gleditsia japonica MIQUEL. III. Further Desmonoterpenyl Glycosides of Echinocystic Acid
- Legume Saponin of Gleditsia japonica MIQUEL. II. Desmonoterpenyl Glycoside of Echinocystic Acid
- 生薬の生物活性成分に関する研究(第2報)サポニン生薬類の抗潰瘍作用および抗炎症作用
- Synthesis and Antitumor Activity of Benzimidazolyl-1,3,5-triazine and Benzimidazolylpyrimidine Derivatives
- Synthesis and Aromatase-Inhibitory Activity of Imidazoly-1,3,5-triazine Derivatives
- Effects of Microinjected Carbachol on the Antinociceptive Response to Noxious Heat Stimuli
- β-Phenylethylamine Stimulates Striatal Acetylcholine Release through Activation of the AMPA Glutamatergic Pathway(Pharmacology)
- Alpha 2-Adrenoceptor Modulates the Release of Acetylcholine from the Rostral Ventrolateral Medulla in Response to Morphine(Pharmacology)
- Modulation of noradrenergic and serotonergic transmission by noxious stimuli and intrathecal morphine differs in the dorsal raphe nucleus of anesthetized rat : in vivo voltammetric studies
- Focal Cerebral Ischemia-Induced Escape Deficit in Rats Is Ameliorated by a Reversible Inhibitor of Monoamine Oxidase-A : Implications for a Novel Animal Model of Post-Stroke Depression
- In vivo voltammetric studies of the effects of intrathecal morphine on noxious heat stimuli-induced serotonin release in the nucleus raphe magnus of anesthetized rats
- STIMULATION OF PERIPHERAL NERVE AND PERIAQUEDUCTAL GRAY MODIFIES THE OXIDATION CURRENT OF 5-HYDROXYINDOLE IN THE SPINAL CORD OF CATS
- In Vitro Cytotoxicity of Imidazolyl-1,3,5-triazine Derivatives
- Possible Therapeutic Effect of T-794,a Novel Reversible Inhibitor of Monoamine Oxidase-A, on Post-Stroke Emotional Disturbances, Assessed in Animal Models of Depression
- Chemical Conversion of Stepinonine to Bisbenzylisoquinoline Alkaloids
- Structure of Stepinonine : a New Dimeric Benzylisoquinoline-2-phenyl-s-homotetrahydroisoquinoline Alkaloid
- 海綿から単離された5環性アルカロイド : マダンガミンA
- タヒボのがん抑制機能の検証 (特集 抗がん研究最前線--機能性食素材の可能性を探る)
- 蛍光標識発癌プロモーターの開発(有機化学・天然物化学-生理活性物質(動物・その他)-)
- 伝統薬物による化学発がん予防に関する研究 XVIII : ウコギ科植物の発がんプロモーター抑制効果
- 海藻の生物活性に関する研究(III) : 発がんプロモーター抑制活性及びアルドース・レダクターゼ阻害活性
- コマクサ培養組織のアルカロイド成分について
- Trachelogenin Methyl EtherからEpitrachelogenin Methyl Etherへの誘導
- 和産「金時ショウガ」の精油成分の季節変動
- 和産「金時ショウガ」の生育ならびに辛味成分とジテルペン成分について
- 生薬のEpstein-Barr Virus活性化抑制作用および抗発癌プロモーター作用について(第1報)
- 防己科植物アルカロイドの薬理作用(そのI) : tetrandrineの薬理作用
- Proaporphine型アルカロイドおよびその誘導体の質量分析