Anti-Tumor-Promoting Activities of Euglobals from Eucalyptus Plants
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概要
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To search for possible anti-tumor-promoters (chemopreventive agents), we carried out a primary screening of 21 euglobals (acylphloroglucinol-monoterpene or -sesquiterpene structures) isolated from the juvenile leaves of five species of Eucalyptus plants using an in vitro synergistic assay system. Of these compounds, euglobal-G1-G5 (1-5), -Am-2 (15) and -III (16) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, the effects of compounds 1 and 16 on the cell cycle of Raji cells were also examined by a flow cytometer, and both compounds 1 and 16 exhibited strong inhibition on the effect of the cell cycle induced by TPA. These two euglobals (1 and 16) exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
- 公益社団法人日本薬学会の論文
- 1995-03-15
著者
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徳田 春邦
京府医大
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木島 孝夫
Kyoto Pharmaceutical University
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高崎 みどり
Kyoto Pharmaceutical University
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小塚 睦夫
Kyoto Pharmaceutical University
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徳田 春邦
京都府立医科大学生化学教室
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徳田 春邦
Department of Biochemistry, Kyoto Prefectural University of Medicine
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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真岡 孝至
Kyoto Pharmaceutical University
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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徳田 春邦
京都府立医大・第一内科
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Maoka T
Sun Biorex Co. Ltd. Kyoto Jpn
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小塚 睦夫
Kyoto Pharmaceutical Univ. Kyoto Jpn
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