防巳科植物アルカロイド研究(第254報) : Stephania rotunda LOUREIROのアルカロイド(補遺その3) : (±)-O-Methylstepharotineの液体アンモニア中金属ナトリウムによる開裂反応
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概要
- 論文の詳細を見る
Ether cleavage reaction of (±)-O-methylstepharotine (XIVa) by metallic sodium in liquid ammonia results in the demethylation of the methoxyl at 9-position of the tetrahydroprotoberberine skeleton to form (±)-9-hydroxy-2,3,10,11-tetramethoxy-5,6,13,13a-tetrahydro-8H-dibenzo [a, g] quinolizine (XXVII). Proof of the structure of the phenolic base (XXVII) was given by a Pictet-Spengler type dibenzoquinolizine synthesis which gave rise to both (XXVII) and (±)-stepharotine (XXVIII).
- 公益社団法人日本薬学会の論文
- 1970-01-25
著者
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小塚 睦夫
Kyoto Pharmaceutical University
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大藪 宏
京都薬科大学
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冨士谷 憲徳
京都大学薬学部
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冨士谷 憲徳
Kyoto Pharmaceutical University
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