防已科植物アルカロイド研究(第224報) : Dauricine型塩基の合成 その1 : 2-Hydroxy-5,4'-bis(2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl-methyl)diphenyl Etherの合成
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概要
- 論文の詳細を見る
dl-Armepavine (VIIIa) and dl-3'-bromo-4'-O-acetylarmepavine (IX) were synthesized and they were submitted to the Ullmann condensation in pyridine, in the presence of potassium carbonate, with copper powder or copper oxide powder as a catalyst, affording the title compound, 2-hydroxy-5,4'-bis(2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl-methyl)diphenyl ether (I). Examination of the infrared and NMR spectra of I indicated that I is a diastereoisomeric racemates having the same planar structure as natural dauri-cine (D, D).
- 公益社団法人日本薬学会の論文
- 1966-08-25
著者
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正木 幸雄
Faculty of Pharmaceutical Sciences, Kyoto University
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青柳 良明
京都大学薬学部
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正木 幸雄
Faculty Of Pharmaceutical Sciences Kyoto University
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青柳 良明
Faculty Of Pharmaceutical Sciences Kyoto University
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冨士谷 憲徳
京都大学薬学部
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正木 幸雄
京都大学薬学部
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冨士谷 憲徳
Kyoto Pharmaceutical University
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