Studies on Peptides. CXV. Synthesis of Hylambatin, a New Frog Skin Peptide of the Kassinin Family
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概要
- 論文の詳細を見る
Hylambatin, a dodecapeptide amide isolated from the skin of an African rhacopharid frog (Hylambates maculatus), was synthesized by two routes, by successive condensations of four fragments, i.e., (1-3), (4-5), (6-10), and (11-12) in one case and (1-3), (4-7), (8-10), and (11-12) in the other, followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The S-alkylation observable during N^α-deprotection of Metcontaining peptides with trifluoroacetic acid was found to be suppressed more effectively by the use of 3,5-dimethylanisole containing 2% ethanedithiol as a scavenger system than by the use of anisole containing 2% ethanedithiol. The contractile potency of synthetic hylambatin in isolated guinea-pig duodenum was 0.42 times that of synthetic kassinin.
- 公益社団法人日本薬学会の論文
- 1984-02-25
著者
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仲田 義啓
広島大学大学院 医歯薬学総合研究科 薬効解析科学
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬川 富郎
Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University
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井上 敦子
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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赤路 健一
Faculty of Pharmaceutical Sciences
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安村 貢一
Fujii, Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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仲田 義啓
Institute of Pharmaceutical Sciences, Hiroshima University
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片倉 晋一
Faculty of Pharmaceutical Sciences, Kyoto University
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冨士谷 憲徳
Kyoto College of Pharmacy, 5 Nakauchi-cho, Yamashina
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岡本 憲治
Kyoto Pharmaceutical University
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矢島 治明
京都大学
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片倉 晋一
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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矢島 治明
京大・薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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安村 貢一
Kyoto College of Pharmacy
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井上 淳子
Institute of Pharmaceutical Sciences, Hiroshima University
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瀬川 富郎
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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片倉 晋一
Research Institute Daiichi Pharmaceutical Co. Ltd.
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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安村 貢一
Fujii Memorial Research Institute Otsuka Pharmaceutical Co. Ltd.
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冨士谷 憲徳
Kyoto Pharmaceutical University
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仲田 義啓
広島大学医学部総合薬学科
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