Intraperitoneal Administration of Senegae Radix Extract and Its Main Component, Senegin-II, Affects Lipid Metabolism in Normal and Hyperlipidemic Mice
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概要
- 論文の詳細を見る
The hypolipidemic effect of Senegae Radix, i.e."Senega, "was investigated in normal and hyperlipidemic mice. The n-butanol fraction of the methanol extract of Senegae Radix (SN) (5mg/kg) significantly reduced the blood triglyceride level of normal mice 7h after intraperitoneal administration (p<0.05) and also significantly reduced the blood triglyceride level of cholesterol-fed mice under similar conditions (p<0.05). SN (5mg/kg) also reduced the blood triglyceride and cholesterol levels after repeated administration to cholesterol-fed mice. SN also decreased the blood triglyceride level in Triton-induced hyperlipidemia. It is suggested that this fraction contains one or more hypolipidemic components including the main triterpenoid glycoside, senegin-II, which significantly reduces the levels of blood triglycerides in normal mice.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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三浦 俊宏
鈴鹿医療科学大学
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Kato A
Natural Medicinal Chemistry Kobe Pharmaceutical University
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MIURA Toshihiro
Suzuka University of Medical Science
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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ICHIMARU Momoyo
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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KATO Atsushi
Kobe Pharmaceutical University
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NISHIYAMA Yumi
Kobe Pharmaceutical University
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Nishiyama Y
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Ichimaru M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu Masataka
Institute Of Pharmacognosy Kobe Women's College Of Pharmacy
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