Cardiotonic Activity of the Rhizome of Polygonatum sibiricum in Rats
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概要
- 論文の詳細を見る
The cardiotonic effect of the rhizome of Polygonatum sibiricum was investigated in the left atria of rats. The methanol extract of the rhizome of Polygonatum sibiricum (OM) (1-7 mg/ml) concentration-dependently increased the developed tension of the left atrium. It also strongly inhibited cAMP phosphodiesterase. The increase cAMP level correlated the increase in left atrial contraction. On the other hand, OM did not inhibit Na^+, K^+-ATPase. The cardiotonic effect of OM was strongly inhibited by reserpine, a sympatholytic agent. Futhermore, OM-treated left atria inhibited the tension produced by propranolol, a beta adrenocepter antagonist. These findings suggested that the cardiotonic effect is due to stimulating beta adrenoceptors through activation of sympathetic nerves.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
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三浦 俊宏
鈴鹿医療科学大学
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Kato A
Natural Medicinal Chemistry Kobe Pharmaceutical University
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MIURA Toshihiro
Suzuka University of Medical Science
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ICHIMARU Momoyo
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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HIRAI Nobuaki
Kobe Pharmaceutical University
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MORIYASU Masataka
Kobe Pharmaceutical University
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ICHIMARU Momoyo
Kobe Pharmaceutical University
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NISHIYAMA Yumi
Suzuka University Medical Science and Technology
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OGURA Kazue
Kobe Pharmaceutical University
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KATO Atsushi
Kobe Pharmaceutical University
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Ogura K
Kobe Pharmaceutical University
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大角 幸治
Central Research Laboratories Ajinomoto Co. Inc.
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Ohsumi Koji
Central Research Laboratories Ajinomoto Co. Inc.
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Nishiyama Y
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Ichimaru M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu Masataka
Institute Of Pharmacognosy Kobe Women's College Of Pharmacy
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