HYPOGLYCEMIC ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP OF IRIDOIDAL GLYCOSIDES
スポンサーリンク
概要
- 論文の詳細を見る
Four iridoidal glycosides, deacetylasperulosidic acid methyl ester (DE), scandoside methyl ester (SC), geniposide (GE) and gardenoside (GA) isolated from Gardenia jasminoides Ellis grandiflora Makino leaves, were tested hypoglycemic activity in mice. DE lowered the blood glucose level in normal mice. However, SC, GE and GA did not affect the blood glucose level in normal mice, indicating that the absolute configuration of 6 position hydroxy based (OH) should be essential for the biological activity.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
-
三浦 俊宏
鈴鹿医療科学大学
-
Kato A
Natural Medicinal Chemistry Kobe Pharmaceutical University
-
MIURA Toshihiro
Suzuka University of Medical Science
-
ICHIMARU Momoyo
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
-
MORIYASU Masataka
Kobe Pharmaceutical University
-
ICHIMARU Momoyo
Kobe Pharmaceutical University
-
KATO Atsushi
Kobe Pharmaceutical University
-
NISHIYAMA Yumi
Kobe Pharmaceutical University
-
Nishiyama Y
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
-
Ichimaru M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
-
Moriyasu M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
-
Moriyasu Masataka
Institute Of Pharmacognosy Kobe Women's College Of Pharmacy
関連論文
- Antidiabetic activity of Cissus sicyoides in KK-Ay mice
- Effect of Fuscoporia obliqua with exercise on blood glucose and lipid in type 2 diabetic mice
- Antidiabetic activity of Fuscoporia oblique and Samallanthus sonchifolius in genetically type 2 diabetic mice(Incentive Award, 2006)
- アルカロイド類の過塩素酸ナトリウムを用いるイオン対抽出及びイオン対高速液体クロマトグラフィーによる迅速分取法(:分離(その1))(抽出・吸着分離)
- 1-メチルアデノシン第四級塩とアクア(ジエチレントリアミン)白金(II)の反応 反応機構, 反応生成物の分離および同定
- Failure in Antitumor Activity by Overdose of an Immunomodulating β-Glucan Preparation, Sonifilan
- Effect of Byakko-ka-ninjin-to with exercise in early stage symptom of non-insulin dependent diabetic mice
- Low-protein dietがラット母体の仔に及ぼす長期的影響 : Spontaneously hypertensive ratでの検討
- GK ラットにおける小腸からのグルコース吸収について:腸管灌流での検討
- P-20 麦門冬飲子の KK-Ay マウスにおよぼす影響
- The Difference in Hypoglycemic Activity between Ginseng Radix and Ginseng Radix Rubra in Normal and Epinephrine-induced Hyperglycemic Mice
- S-2 黄精の血糖低下作用と糖輸送担体におよぼす影響
- The Suppressive Effect of Mangiferin with Exercise on Blood Lipids in Type 2 Diabetes
- Hypolipidemic activity of Mangiferin in cholesterol-fed mice
- New Antidiabetic Compounds, Mangiferin and Its Glucoside
- Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice(Pharmacognosy)
- Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice
- Hypoglycemic Activity of the Fruit of the Momordica charantia in Type 2 Diabetic Mice
- Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside
- Effect of Alpha-Linolenic Acid on Blood Glucose, Insulin and GLUT4 Protein Content of Type 2 Diabetic Mice
- Effect of Epinephrine of GLUT2 Protein Content in Mouse Liver
- II-B-20 漢方生薬の臨床的分類 : "血"薬を中心に血小板凝集抑制作用を指標にして
- II-B-11 煎出条件が漢方薬におよぼす影響 : 〓呂薤白白酒湯について
- Tropane alkaloids from Erythroxylum emarginatum
- Quaternary Isoquinoline Alkaloids from Monodora junodii and M. grandidieri
- Cytotoxic C-Benzylated Dihydrochalcones from Uvaria acuminata
- Isoquinoline Alkaloids from Monodora grandidieri
- High-Performance Liquid Chromatographic Determination of Organic Substances by Metal Chelate Derivatization. III. Analysis of Ephedra Bases
- Effect of Polygonati Rhizoma on Blood Glucose and Facilitative Glucose Transporter Isoform 2 (GLUT2) mRNA Expression in Wistar Fatty Rats
- Hypocholesterolemic Activity of Polygonati Rhizoma
- Urinary Growth Hormone Excretion is Increased in the Patients with Non-Insulin Dependent Diabetes Mellitus Complicated with Diabetic Microangiopathy.
- HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHITOSAN IN NORMAL AND NEONATAL STREPTOZOTOCIN-INDUCED DIABETIC MICE
- OLETFラットにおける小腸からのグルコース吸収について
- EFFECT OF SENEGIN-II ON BLOOD GLUCOSE IN NORMAL AND NIDDM MICE
- Hypoglycemic Effect of the Rhizomes of Ophiopogonis Tuber in Normal and Diabetic Mice
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Antidiabetic Effects of Corosolic Acid in KK-Ay Diabetic Mice(Pharmacognosy)
- 30C-14 ブラジル産 Guarana 水抽出物の滋養強壮作用
- Corosolic Acid Induces GLUT4 Translocation in Genetically Type 2 Diabetic Mice(Pharmacognosy)
- Antidiabetic Mechanism of Bakumondo-inshi
- Docosahexanoic Acid (DHA) Improved Glucose and Lipid Metabolism in KK-A^y Mice with Genetic Non-Insulin-Dependent Diabetes Mellitus
- EFFECT OF GINSENG RADIX ON GLUT2 PROTEIN CONTENT IN MOUSE LIVER IN NORMAL AND EPINEPHRINE-INDUCED HYPERGLYCEMIC MICE
- Determination of Hemoglobin A_ in Normal and Diabetic Mice : Neonatal Streptozotocin-Induced Diabetic Mice and KK-Ay Mice
- Antidiabetic activity of Fuscoporia oblique in KK-Ay mice
- The Difference in Hypoglycemic Action between Polygonati Rhizoma and Polygonati Officinalis Rhizoma
- Effects of Steroidal Glycosides on Blood Glucose in Normal and Diabetic Mice
- Hypoglycemic Activity of Polygonati Rhizoma in Normal and Diabetic Mice
- Induction of Apoptosis in Human Promyelocytic Leukemia Cell Line HL-60 by C-Benzylated Dihydrochalcones, Uvaretin, Isouvaretin and Diuvaretin(Medicinal Chemistry)
- Cardiotonic Activity of the Rhizome of Polygonatum sibiricum in Rats
- Cardiotonic Activity of Root of Citrus junos Sieb.ex Tanaka
- Intraperitoneal Administration of Senegae Radix Extract and Its Main Component, Senegin-II, Affects Lipid Metabolism in Normal and Hyperlipidemic Mice
- HYPOGLYCEMIC ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP OF IRIDOIDAL GLYCOSIDES
- Cancer Chemopreventive Activity of 2-(2, 3, 6-Trihydroxy-4-carboxyphenyl) ellagic Acid from the Fruits of Casealpinia ferrea
- Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice
- Effect of Corosolic Acid on the Hydrolysis of Disaccharides
- ANALYSIS IN SITU OF CELL CONTENT BY MEANS OF AUTOMATIC HISTOCHEMICAL CHROMATOGRAPHY
- Hypoglycemic Effect of the Rhizomes of Smilax glabra in Normal and Diabetic Mice
- Antihypoglycemic effect of Maca in fasted and insulin-induced hypoglycemic mice
- 糖尿病の発生機序とグルコ-ストランスポ-タ- (グルコ-ストランスポ-タ-)
- 糖尿病と糖輸送担体 (レセプタ-と病態モデル)
- PA121 STEREOCHEMICAL STUDY OF GUINESINES, SULFUR CONTAINING ALKALOIDS, BASED ON NMR RELAXATION PARAMETERS
- Antidiabetic effect of the herb Myrcia speciosa in KK-Ay diabetic mice
- Hypoglycemic and hypolipidemic activity of the leaf of Samallanthus sonchifolius in genetically type 2 diabetic mice
- Hydroxyespintanol and schefflerichalcone : two new compounds from Uvaria scheffleri
- Antinociceptive effects of the extracts of Xylopia parviflora bark and its alkaloidal components in experimental animals
- Hypogycemic and Aldose Reductase Activity of Polichia campestris
- Fungicidal and Herbicidal Activities of Berberine Related Alkaloids
- Effect of Methanol Extract of Phellodendri Cortex on Lipid Metabolism in Normal and Hyperlipidemic Mice
- Hypoglycemic Action of Stigma of Zea mays L. in Normal and Diabetic Mice
- Quaternary Isoquinoline Alkaloids from Monodora junodii and M. grandidieri
- Isoquinoline Alkaloids from Monodora grandidieri
- Hypoglycemic Activity of To-Kai-San (Chinese Medicines) in Normal and KK-Ay Mice
- A Comparative Study of High-Fat Diet Containing Fish Oil or Lard on Blood Glucose in Genetically Diabetic (db/db) Mice
- Secondary and Tertiary Isoquinoline Alkaloids from Monodora junodii
- Isoquinoline Alkaloids from Monodora junodii(Natural Medicine Note)
- Cardiotonic Activity of Root of Citrus junos SIEB. ex TANAKA
- Cardiotonic Action of the Root of Citrus reticulata
- Isolation of Alkaloids from Plant Materials by the Combination of Ion-pair Extraction and Preparative Ion-pair Chromatography Using Sodium Perchlorate. II : Sinomeni Caulis et Rhizoma
- Isolation of Alkaloids from Plant Materials by the Combination of Ion-pair Extraction and Preparative Ion-pair HPLC Using Sodium Perchlorate. I : Magnoliae Cortex
- Evaluation of Crude Drugs by a Combination of Enfleurage and Chromatography (V) : On Flavor Components in Rhizoma of Notopterygium sp., and in Roots of Angelica pubescens and Aralia cordata
- Evaluation of Crude Drugs by a Combination of Enfleurage and Chromatography (III) : On Flavor Components in Seeds of Amomum xanthioides, Alpinia katsumadai and Amomum tsao-ko
- Analysis of Alkaloids in Nandina domestica by Means of HPLC and TLC-Densitometry
- Determination of Sweet Components in Stevia rebaudiana by High-Performance Liquid Chromatography : Ultraviolet Detection
- Effect of Acarbose (α-Glucosidase Inhibitor) on Disaccharase Activity in Small Intestine in KK-Ay and ddY Mice
- Chemical studies on the roots of Uvaria welwitschii
- Evaluation of Crude Drugs by a Combination of Enfleurage and Chromatography (IV) : On Flavor Components in Seeds of Amomum cardamomum and Elettaria cardamomum
- Pyrenes and pyrendiones from Uvaria lucida
- Studies on African Medicinal Plants : Alkaloidal Constituents of Uvaria acuminata and Uvaria lucida
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. IV. Separation of rotamers of palladium(II) dithiocarbamates.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. III. Ternary complex formation between Ni(II) diethyldithiocarbamate and other unlike Ni(II) chelates.
- Kinetic studies of fast equilibrium by high-performance liquid chromatography I. Ternary complex formation of N,N-disubstituted dithiocarbamate chelates of Ni(II) and Cu(II).
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. VI. Separation of rotamers of formanilide.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. XII. Rate constants and energy barriers of intramolecular carbonyl-nitrogen bond rotation of o-substituted acetanilides.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. X. Separation of rotamers of acetanilides.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. XIII. Separation of rotamers of N-alkyl-substituted amides.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. V. Stepwise complex formation of the nickel(II) ion with 2,2'-bipyridine and 1,10-phenanthroline.
- Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. II. Ligand exchange of N,N-disubstituted dithiocarbamate chelates of Ni(II).
- Isoquinoline Alkaloids from Monanthotaxis trichocarpa
- Studies on African Medicinal Plants Alkaloidal Constituents of Uvaria acumina ta and Uvaria lucida
- Evaluation of Crude Drugs by a Combination of Enfleurage and Chromatography (II) : On Flavor Components in Fruits of Forsythia suspensa