Induction of Apoptosis in Human Promyelocytic Leukemia Cell Line HL-60 by C-Benzylated Dihydrochalcones, Uvaretin, Isouvaretin and Diuvaretin(Medicinal Chemistry)
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概要
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Uvaretin, isouvaretin and diuvaretin, cytotoxic C-benzylated dihydrochalcones isolated from Uvaria acuminata, displayed growth inhibitory effects against human promyelocytic leukemia HL-60 cells. We examined the mechanism of the cytotoxicity. From the morphological study by staining with Hoechst 33258, the cells treated with C-benzylated dihydrochalcones exhibited significant chromosomal condensation and nuclear degradation. The cell cycle analysis showed the accumulation of cells in the G_1 phase and the appearance of a sub-G_1, peak. These results suggest apoptotic cell death. Further, from the detection of DNA fragmentation and the activation of caspase-3, the biological hallmarks of apoptosis, these C-benzylated dihydrochalcones appeared to induce apoptosis against HL-60 cells. The cytotoxicity of uvaretin and diuvaretin was stronger than that of isouvaretin, which suggest that the 5'-substitution of the 2-hydroxybenzyl group increased the cytotoxicity.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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Kato A
Natural Medicinal Chemistry Kobe Pharmaceutical University
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KATO Atsushi
Department of Hostpital Pharmacy, Graduate School of Medicine and Pharmaceutical Sciences, Universit
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Kato Atsushi
Department Of General Surgery Chiba University Graduate School Of Medicine
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ICHIMARU Momoyo
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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NAKATANI Noriyoshi
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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MORIYASU Masataka
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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Ichimaru M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu Masataka
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu M
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Moriyasu Masataka
Institute Of Pharmacognosy Kobe Women's College Of Pharmacy
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Nakatani Noriyoshi
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Kato Atsushi
Department Of Biological Science Graduate School Of Life And Environment Science Shimane University
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