Hypoglycemic Effect of the Rhizomes of Smilax glabra in Normal and Diabetic Mice
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概要
- 論文の詳細を見る
The hypoglycemic effect of the rhizomes of Smilax glabra ROXBURGH (Liliaceae) was investigated in normal and KK-Ay mice, one of the animal models of non-insulin dependent diabetes mellitus (NIDDM) with hyperinsulinemia.The methanol extract of rhizomes of Smilax glabra ROXBURGH (SM, 100 mg/kg body weight) reduced the blood glucose of normal mice 4 h after intraperitoneal administration (p<0.05), and also significantly lowered the blood glucose of KK-Ay mice under similar conditions (p<0.001). However, SM did not affect the blood glucose in streptozotocin-induced diabetic mice, one of the animal models of insulin-dependent diabetes mellitus (IDDM) with hypoinsulinemia. SM also suppressed epinephrine-induced hyperglycemia in mice. SM-treated KK-Ay mice significantly decreased the blood glucose in an insulin tolerance test. We concluded that the hypoglycemic effect of SM raised insulin sensitivity.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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MIURA Toshihiro
Suzuka University of Medical Science
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KATO Atsushi
Kobe Pharmaceutical University
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Kato A
Kobe Pharmaceutical University
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FUKUNAGA Tomoji
Mayado Pharmaceutical Co., Ltd.,
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FURUTA Ko
Mayado Pharmaceutical Co., Ltd.,
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Furuta Ko
Mayado Pharmaceutical Co. Ltd.
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Fukunaga T
Mayado Pharmaceutical Co. Ltd.
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Miura Toshihiro
Suzuka University Of Medical Science And Technology
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FUKUNAGA Tomoji
Mayado Pharmaceutical Co. Ltd.
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