Synthesis and Antitumor Activity of Benzimidazolyl-1,3,5-triazine and Benzimidazolylpyrimidine Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Triamino-substituted 1,3,5-triazine and pyrimidine derivatives were synthesized and tested for antimtuor activities using some human cancer cell lines and murine leukemia cell lines. All the compounds having benzimidazolyl and morpholino groups as substituents on the 1,3,5-traizine ring showed antitumor activity. Pyrimidine derivatives having the same groups as substituents also showed antitumor activity. Among them, the compounds having 1-benzimidazolyl, morpholino and cis-2,3-dimethylmorpholino groups as substituents on the 1,3,5-triazine ring or pyrimidine ring exhibited the most potent antitumor activity, and these compounds exhibited no or very weak aromatase inhibitory activity. In contrast, the compounds having imidazolyl group instead of benzimidazolyl group as a substituent on the 1,3,5-triazine ring showed a potent aromatase inhibitory activity.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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Kato M
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kawashima Seiichiro
Research Laboratory, Zenyaku Kogyo Co.,Ltd.
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MATSUNO Toshiyuki
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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加藤 眞行
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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加藤 昌子
奈良女大院人間文化
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Takahashi M
Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation
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YOSHIOKA Kimitomo
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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SAKATO Mitsuo
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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Matsuno Toshiyuki
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima Seiichiro
Research Laboratory Zenyaku Kogyo Co. Ltd.
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KATO Masanobu
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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SASAHARA Hiroya
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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WATANABE Tetsuo
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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INABA Masahiro
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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TAKAHASHI Masayuki
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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YAGUCHI Shin-ichi
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Tada M
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Sakato Mitsuo
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Inaba M
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Matsuno T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Matsuno T
Kyoto Pharmaceutical University
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Sasahara Hiroya
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Yoshioka K
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Yoshioka Kimitomo
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Yaguchi S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Tsukatani Masaki
Faculty Of Pharmaceutical Science Kobe Gakuin University
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Watanabe Tetsuo
Research Division Toyo Jozo Co. Ltd.
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KAWASHIMA Seiichiro
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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