Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat
スポンサーリンク
概要
- 論文の詳細を見る
Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. ZSET845 (0.01 mg/kg) showed a greater ameliorative effect than donepezil (0.1 mg/kg) or tacrine (1 mg/kg) in the passive avoidance task. In the radial-arm maze task, ZSET845 (0.1 mg/kg) also showed a greater effect than donepezil (10 mg/kg) or tacrine (10 mg/kg). ZSET845 induced an increase in the choline acetyltransferase (ChAT) activity in the hippocampus, suggesting that the ameliorative effects of ZSET845 are related to the increase in the ChAT activity in the hippocampus.
- 社団法人 日本薬理学会の論文
- 2001-11-01
著者
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Kawashima Seiichiro
Research Laboratory, Zenyaku Kogyo Co.,Ltd.
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Yamaguchi Y
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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Yamaguchi Yoshimasa
全薬工業研究所
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YAMAGUCHI Yoshimasa
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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HIGASHI Masaya
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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MATSUNO Toshiyuki
Research Laboratory, Zenyaku Kogyo Co., Ltd.
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Higashi Masaya
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Matsuno Toshiyuki
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Yamaguchi Yoshimasa
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima Seiichiro
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima Seiichiro
Department Of Biosciences Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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