Stimulation of Neuronal Process Growth by Estradiol-17β in Dissociated Cells from Fetal Rat Hypothalamus-Preoptic Area(Endocrinology)

概要

論文の詳細を見る
The morphogenetic effects of estradiol-17β (E_2) have been assessed in primary culture of dissociated cells from fetal rat hypothalamus-preoptic area and cerebral cortex. In cultures of the hypothalamus-preoptic area from fetuses on Day 21 of gestation, E_2 significantly increased the total neuronal process length after 2 or 4 days of culture as compared with the control cultures. The degree of stimulation was not different between male and female fetal preparations. While, in neurons of the hypothalamus-preoptic area from fetuses on Day 17 of gestation stimulatory influence of E_2 was not detected. None of the cerebral cortical neurons from fetuses on Day 17 or 21 of gestation showed E_2 response. Neither percentages of unipolar, bipolar and multipolar neurons nor the mean number of neuronal process termini showed significant differences between control and E_2-treated cultures of the hypothalamus-preoptic area or the cerebral cortex from fetuses on Day 17 or 21 of gestation. The present findings of the stimulation of process growth by E_2 in neurons of the hypothalamuspreoptic area of Day 21 fetuses but not of Day 17 fetuses may indicate the presence of sufficient concentration of estrogen receptors in Day 21 fetus preparations to induce E_2 response.
社団法人日本動物学会の論文
1985-06-15