Effects of Unilateral and Bilateral Orchidectomy on Laterality of Neurons of the Preoptic Area and Plasma Levels of Gonadotropins and Testosterone in Male Mice(Endocrinology)
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概要
- 論文の詳細を見る
Possible involvement of direct neural connections between the testes and the hypothalamus in the neuroendocrine control of gonadal function was studied in male mice. Two-month-old male mice of the CD-1 strain were orchidectomized either unilaterally or bilaterally and changes in the size of neuronal nuclei and cell bodies in the medial preoptic area (POA) and plasma concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone were examined one week after operation. Both nuclei and cell bodies of POA neurons were significantly larger in the right side of the brain than in the left side. Either unilateral or bilateral orchidectomy failed to abolish the left-right difference. On the other hand, bilateral orchidectomy and removal of the left testis consistently caused a significant reduction in the size of neuronal nuclei on both sides of the POA, while removal of the right testis induced a significant decrease in the size of neuronal nuclei on the right side of the POA alone. By contrast, the cell body size of both sides of the POA was significantly larger in animals removed of their right testes than in those subjected to bilateral, left-sided or sham orchidectomy. Bilateral and unilateral orchidectomy caused a significant increase in plasma LH levels, but failed to show a significant elevation in plasma FSH levels. Removal of either side of the testis invariably caused an increase in plasma levels of testosterone. The present experiments clearly exhibited the left-right difference in the morphology of POA neurons in male mice. The results further suggest that the neural connections between the testes and the hypothalamus are involved in the control of hypophyseal-gonadal functions in male mice.
- 社団法人日本動物学会の論文
- 1992-04-15
著者
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Kawashima Seiichiro
Zoological Institute, Graduate School of Science, University of Tokyo
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Nakazawa Toshiyuki
Zoological Institute Faculty Of Science Hiroshima University
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Machida Takeo
Zoological Institute Faculty Of Science Hiroshima University
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Kawashima Seiichiro
Zoological Institute Faculty Of Science Hiroshima University
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