Stimulation of Nuclear Volume Enlargement and Neuronal Process Growth by Estrogen in the Hypothalamic and Limbic Nuclei of the Rat : Endocrinology

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Effects of estradiol-17β (E_2) on the growth of nuclear volume of the ventromedial nucleus (VMN), the suprachiasmatic nucleus (SCN) and the bed nucleus of the stria terminalis (STN), and the growth of neuronal process length in these nuclei were studied. Male and female rats of the Wistar/Tw strain were castrated on the day of birth (Day 1), and were given subcutaneous injections of 10μg E_2 daily for the first 10 postnatal days. They were killed on Days 11 and 31. E_2 treatment generally stimulated the growth of the nuclear volume and the neuronal process length in the VMN. However, the E_2 effect was not significant in the nuclear volume of the VMN in males on Day 31 and in the neuronal process length in females on Day 11. In the SCN, E_2 failed to stimulate the nuclear volume enlargement, but it was effective for the neuronal process elongation only on Day 31. In the STN, E_2 stimulated the growth of nuclear volume on Day 31 in males and on Day 11 in females and the neuronal process length on Day 11 in males. The present results showed that the E_2 effects were marked in the VMN but were less evident in the SCN and STN, and that the E_2 response in the nuclear volume in a nucleus was generally accompanied by a similar stimulatory effect of E_2 in the neuronal process growth in the nucleus, indicating that the nuclear volume enlargement is due, at least partly, to the neuronal process growth.
社団法人日本動物学会の論文
1989-08-15