Fetal and Postnatal Development of Arginine Vasopressin-Immunoreactive Neurons in the Mouse : Endocrinology

概要

論文の詳細を見る
The ontogeny of arginine vasopressin (AVP)-producing neurons in the hypothalamo-neurohypophysial system (HNS) was immunocytochemically studied in fetal and postnatal mice. Presumptive AVP neurons underwent proliferation in the vicinity of the third ventricle and migrated to settle in the final loci by fetal age of 18days (FA 18). AVP-immunoreactive neurons were first detected on FA 14 in the presumptive supraoptic (SON) and retrochiasmatic nuclei (RCN). AVP-immunoreactive axons and terminals were present in the median eminence and pars nervosa of the neurohypophysis on FA 15, but not on FA 14. Immunoreactive neurons were recognized in the paraventricular nucleus (PVN) on FA 15 and their terminals in the external layer of the median eminence became immunoreactive on FA 18. In the suprachiasmatic nucleus (SCN) AVP-immunoreactive perikarya appeared on FA 16. The number of AVP neurons in the SON and RCN markedly increased during fetal life. Postnatal increase in the number of immunoreactive neurons in the PVN and SCN as well as that of the SON and RCN was apparent. To sum up, the present study shows that cytodifferentiation of AVP-producing neurons in the HNS takes place during early days of last trimester of pregnancy and that the HNS completes the general morphological changes before birth.
社団法人日本動物学会の論文
1988-10-15