Luteinization of Ovarian Transplants in Gonadectomized Male and Female Rats under Stressful Conditions and Its Relation to Sexual Differentiation of the Hypothalamus

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In the 1st series of experiments, male and female rats were gonadectomized at 10 days of age and simultaneously given subcutaneous syngenesio-or autotransplants of an ovary. At 25 days of age a group of the rats were subjected to stressful stimuli by making a subcutaneous croton oil pouch. Another group of the rats not exposed to stress served as controls. When they were sacrificed at 35 days of age, corpora lutea (CL) were never found in the ovarian grafts in both the control and stressed female rats. On the contrary, in 7 out of 12 stressed male hosts the grafts contained well developed CL, although those in the control animals invariably lacked them. In the 2nd series of experiments, male rats were orchidectomized on the day after birth, all the other procedures being similar to those in the preceding series. At sacrifice, CL were encountered in theovarian grafts in 6 out of 11 control rats. However, in 10 similar rats exposed to stressful stimuli, CL were formed in only one animal.These and the writer's previous findings seem to indicate that an increase in the release of GTH, LH in particular, following exposure to stressful stimuli is in some way associated with the male pattern of GTH secretion.
社団法人日本内分泌学会の論文