Design of Plasma Kallikrein Inhibitors : Functional and Structural Requirements of Plasma Kallikrein Inhibitors

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概要

• 論文の詳細を見る

• The synthetic plasma kallikrein (PK) inhibitor trans-4-aminomethylcyclohexanecarbonylphenylalanine-4-carboxymethylanilide (PKSI-527) consists of three parts. Each part was replaced by analogues in an attempt to improve the potency and the selectivity of PKSI-527. Among the peptides examined, trans-4-aminomethylcyclohexanecarbonylphenylalanine-4-carboxyanilide (peptide 16) inhibited PK with a high selectivity and an IC_<50> value of 2.7μM, being as potent as PKSI-527.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Hijikata-Okunomiya Akiko

  Faculty of Health Science, Kobe University School of Medicine

• Okamoto Shosuke

  Kobe Research Projects on Thrombosis and Haemostasis

• TADA Mayako

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• WANAKA Keiko

  Kobe Research Projects on Thrombosis and Haemostasis

• Hijikata‐okunomiya A

  Faculty Of Health Science Kobe University School Of Medicine

• Hijikata-okunomiya Akiko

  Faculty Of Health Science Kobe University School Of Medicine

• Okamoto Shosuke

  Kobe Research Projects On Thrombosis And Haemostatis

• Wanaka Keiko

  Kobe Research Projects On Thrombosis And Haemostatis

• TADA Mayako

  Kobe Research Projects on Thrombosis and Haemostasis

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• 岡本 成羽

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

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