A NOVEL METHOD FOR INDUCTION AND DETECTION OF ANAPHYLACTIC REACTION USING THE MOUSE ABDOMINAL WALL (AW METHOD)

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概要

• 論文の詳細を見る

• We found that an antigen-specific anaphylaxis was induced by antigen challenge to the abdominal wall, ear auricle, or subcutaneous tissue in mice sensitized 9 days previously with antigen and adjuvant. The anaphylactic reaction was detected by vascular permeability at the injected site 7 minutes after challenge, which was the best time for estimation. A novel method (AW method) for induction and detection of the anaphylactic reaction in mice was established using the abdominal wall as the challenge site. This method could detect the anaphylactic response in mice 1 to 3 weeks after sensitization. The increase in vascular permeability was completely inhibited by administration of diphenhydramine.

• 公益社団法人日本薬学会の論文
• 1997-06-15

著者

• 伊藤 裕二

  Department Of Pharmaceutics Research Center Taisho Pharmaceutical Co. Ltd.

• Semma Masanori

  School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University

• Semma Masanori

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Ito Yoshihisa

  College Of Pharmacy Nihon University

• Kataoka Hiromi

  School Of Pharmaceutical Sciences Mukogawa Women 's University

• KATAOKA Hiromi

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Ito Yoshihisa

  Res. Unit Of Pharmacology Dep. Of Clinical Pharmacy School Of Pharmacy Nihon Univ. Jpn

• TSUDA Yoshimi

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• ITO Yoshio

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• TSUDA Akiko

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• BABA Akiko

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• YOSHIDA Harumi

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• HIRASAWA Reiko

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• TOBIMATSU Yoshie

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• NISHIGUCHI Minori

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Ito Y

  Nihon Univ. Funabashi Jpn

• Baba Akiko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Tsuda Akiko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Yoshida Harumi

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Hirasawa Reiko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Nishiguchi Minori

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• Ito Yuji

  Otc Product R & D Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Ito Yoshio

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• SEMMA Masanori

  Faculty of Pharmaceutical Science, Mukogawa Women's University

• ITO Yoshio

  Faculty of Pharmaceutical Science, Mukogawa Women's University

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