Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands

スポンサーリンク

概要

• 論文の詳細を見る
• 2004-03-01

著者

• 津田 喜典

  金沢大学薬学部

• AMBO Akihiro

  Tohoku Pharmaceutical University

• SASAKI Yusuke

  Tohoku Pharmaceutical University

• Yokoi T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:cooperative Research Center Of Life Scienc

• Lazarus L

  Medicinal Chemistry Group Lpc National Institute Of Environmental Health Sciences

• Tsuda Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Ambo A

  Tohoku Pharmaceutical University

• Sasaki Y

  Tohoku Pharmaceutical University

• 津田 喜典

  金沢大

• Shimohigashi Yasuyuki

  Laboratory Of Structure-function Biochemistry Department Of Molecular Chemistry Graduate School Of S

• YOKOI Toshio

  The Graduate School of Food and Medicinal Sciences, Kobe Gakuin University

• BRYANT Sharon

  Medicinal Chemistry Group, LPC, National Institute of Environmental Health Sciences

• FUJITA Yoshio

  Fuculty of Pharmaceutical Sciences, Kobe Gakuin University

• LI Tignyou

  High Technology Research Center, Kobe Gakuin University

• YOKOI Toshio

  Fuculty of Pharmaceutical Sciences, Kobe Gakuin University

• TSUDA Yuko

  Fuculty of Pharmaceutical Sciences, Kobe Gakuin University

• BRYANT Sharon

  Oeotides Neurochemistry, LCBRA, National Institute of Environmental Health Sciences, Research Triang

• OKADA Yoshio

  Fuculty of Pharmaceutical Sciences, Kobe Gakuin University

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Bryant Sharon

  Medicinal Chemistry Group Lpc National Institute Of Environmental Health Sciences

• Li Tingyou

  The Graduate School Of Food And Medicinal Sciences And Faculty Of Pharmaceutical Sciences Kobe Gakui

• Yokoi T

  Kobe‐gakuin Univ. Hyogo Jpn

• Fujisawa Yutaka

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Yamamoto T

  R&d Laboratories Nippon Organon K.k.

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• Sasaki Yusuke

  Tohoku College Of Pharmacy

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

関連論文

• 糖類水酸基の一選択的修飾と変換 : スズ化合物による水酸基の選択的活性化
• Anthelmintic Effect of the Embelia ribes Decoction and Embelin Derivatives on Trichuris muris in Mice
• Trichuris muris : The Anthelmintic Effect of Mebendazole in Mice is Dependent upon the Pre-treatment with Steroids
• Mobility Inhibition and Nematocidal Activity of Asarone and Related Phenylpropanoids on Second-Stage Larvae of Toxocara canis
• A Tetrazorium Dye (MTT) Assay for Testing Larval Viability Using Second-Stage Larvae of Toxocara canis
• Barbaloin Stimulates Growth of Eubacterium sp. Strain BAR, a Barbaloin-Metabolizing Bacterium from Human Feces
• Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
• Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
• Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
• REARRANGEMENT OF 2,3-DIOXO-1,4-OXAZINES TO 4,5-DIOXOOXAZOLES IN THE REACTION WITH DIMETHYLSULFOXONIUM METHYLIDE
• Dioxypyrrolines. LV. Stereochemical Pathway of [2+2]Photocycloaddition Reaction of 4,5-Diethoxycarbonyl-1H-pyrrole-2,3-dione to Cycloalkadienes and Cycloalkenes
• Dioxopyrrolines. LIII.Stereochemical Pathway of [2+2] Photocycloaddition Reaction of 4-Ethoxycarbonyl-5-phenyl-1H-pyrrole-2,3-dione to Cyclic Enol Trimethylsilyl Ethers
• 茯苓の研究-1-菌核の産出状況および形態
• 色彩計による生薬の品質評価-1-粉末生薬の測定条件と人参類生薬の品質評価
• Reaction of Phenylselenenyl Chloride with Δ^2-Erythrinans in Methanol : Conformational Fluctuation and Stereochemical Pathway
• Synthesis of Erythrina and Related Alkaloids.XXIV. Total Synthesis of Erysotrine from 1,7-Cycloerythrinan Derivatives by the Use of a New 1,2-Carbonyl Transposition Method
• Photo-Cycloaddition of 3-Methoxycyclohexenone and 3-Aminocyclohexenone to Ethoxyethylene : Stereochemistry of the Cycloadducts
• SYNTHESIS OF SOME DEOXY, UNSATURATED, AND DIDEOXY SUGARS VIA REGIOSELECTIVE THIOACYLATION OF GLYCOPYRANOSIDES BY THE DIBUTYLTIN OXIDE METHOD
• Regioselective Monotosylation of Non-protected and Partially Protected Glycosides by the Dibutyltin Oxide Method
• 26 ホモエリスリナアルカロイド,(±)schelhammericine,(±)3-epischelhammericineの全合成
• TOTAL SYNTHESIS OF THE HOMOERYTHRINAN ALKALOIDS, SCHELHAMMERICINE AND 3-EPISCHELHAMMERICINE
• Conversion of Thiocarbonyl into Carbonyl Group by O-S Exchange Reaction with Dibutyltin Oxide or Bistributyltin Oxide
• Synthesis of Malabaricones, Diarylnonanoids Occurring in Myristicaceous Plants
• A NEW 1,2-CARBONYL TRANSPOSITION METHOD VIA PHENYLSELENENYLATION. HIGH YIELD TRANSFORMATION OF O-METHYLESTRONE TO O-METHYLISOESTRONE
• DNA Profiling of Acorus calamus Chemotypes Differing in Essential Oil Composition
• Amino Acids and Peptides. LV. Application of 2-Adamantyl Dericatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. II
• Amino Acids and Peptides. LIV. Application of 2-Adamantyl Derivatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. I
• Infrared Spectra of Conjugated Amides : Reassignment of the C=O and C=C Absorptions
• Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
• Deprotection of the Indole (N^)_Formyl (For) Group on Tryptophan Employing a New Reagent, N,N'-Dimethylethylendiamine (DMEDA) in an Aqueous Solution
• Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
• Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
• Synthesis and Biological Activity of Opioid Peptides Replaced Phenylalanine at Position 3 or 4 by 2, 6-Dimethylphenylalanine
• Biological Properties of Opioid Peptides Replacing Tyr at Position 1 by 2,6-Dimethyl-Tyr
• Detecting of Anaphylactic Reaction in the Percutaneously Sensitized Mouse Using the AW Method
• Suppression and Enhancement of the Freund's Incomplete Adjuvant-Induced Writhing Reaction by Sodium Ascorbate in Mice
• Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety : Confirmation of Stereostructure by X-Ray Analysis
• The Antiproliferative Activities of Somatostatin Analogs on Various Tumor Cells
• Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
• Studies on the Mechanism of 1,2-Dihydropyrazin-2-one Ring Formation from Dipeptidyl Chloromethyl Ketone and Its Chemical Properties : Immediate Deamination during Catalytic Hydrogenation
• Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
• Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
• Synthesis of Somatostatin Analogs and Their Antitumor Activities
• The Structure-Activity Relationship of Dmt-NH-X
• Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
• Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
• Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Their Activities
• Structure-Inhibitory Activity Relationship of Plasmin and Plasma Kallikrein Inhibitors^
• Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization
• スピロ型構造を持ったアルカロイド群の全合成
• 日本薬学会奨励賞受賞森裕二氏の業績
• 白樺6大学合同セミナーなど(研究者の能力を高めるために実行している教育)
• ヒガンバナ科アルカロイドの全合成
• "薬とは何か"の化学(薬品化学で何を教えるか)
• 日本薬学会学術賞紹介-2 : 藤田栄一氏の業績
• 医薬品の開発と天然物化学(薬学領域において天然物化学研究に託される役割り)
• I-C-9 腸内細菌による和漢薬成分の代謝(第 22 報) : Eubacterium sp. BAR における Barbaloin 代謝酵素の誘導
• Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
• Isolation and Structure Elucidation of Gymnemic Acids, Antisweet Principles of Gymnema sylvestre
• TRIALKYLTIN RADICAL USED TO CATALYZE THE O,S-REARRANGEMENT OF CYCLIC THIONOCARBONATES. A NEW ENTRY TO THIO-SUGARS(Communication to the Editor)
• Studies on the Stable Structure and Inhibitory Activity of Plasmin and Plasma Kallikrein Inhibitors Using the MM+ Force Field
• Synthesis of Cyclic Peptides with Agonist Activity for Melanocortin Receptors
• Receptor Binding Properties and Antinociceptive Effects of Chimeric Peptides Consisting of a μ-Opioid Receptor Agonist and an ORL1 Receptor Antagonist(Medicinal Chemistry)
• Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
• 天然由来殺寄生虫物質
• TWO NEW GYMNEMIC ACID CONGENERS CONTAINING A HEXULOPYRANOSIDE MOIETY
• Z-E Isomerization of β-Methoxychalcones : Preferred Existence of E-Isomers in Naturally Occurring β-Methoxychalcones
• Regio- and Stereo-Selective Transformation of Glycosides to Amino-glycosides : Practical Synthesis of Amino-sugars, 4-Amino-4-deoxy-D-galactose, 4-Amino-4-deoxy-L-arabinose, 3-Amino-3-deoxy-D-allose, 3-Amino-3-deoxy-D-glucose, 3-Amino-3-deoxy-D-ribose, 3-
• Regioselective Mono-oxidation of Non-protected Carbohydrates by Brominolysis of the Tin Intermediates
• Selective Deoxygenation via Regioselective Thioacylation of Non-protected Glycopyranosides by the Dibutyltin Oxide Method(Organic,Chemical)
• Hexahydro-dibenz[d, f]azecines : Existence of Two Conformational Isomers of the 6-Oxo Derivatives in Solution
• The Structure-Activity Relationship of [Dmt^1]Endomorphin-2 Derivatives
• The Structure-Activity Relationship of the Opioidmimetics Containing 2(1H)-Pyrazinone Ring as a Linker and Observation of Deamination during Synthesis
• Design of Opioidmimetics : Dimerization of 2', 6'-Dimethyl-L-Tyrosine
• Nociceptin and Dynorphin A Analogues with Dmp Substituted for N-Terminal Aromatic Residues
• 2',6'-Dimethylphenylalanine (Dmp) Can Mimic the N-Terminal Tyr in Opioid Peptides(Medicinal Chemistry)
• Biological Activity of Dermorphin and Deltorphin-II Analogs Replaced Phenylalanine at Position 3 by 2,6-Dimethylphenylalanine
• Regioselective Monoalkylation of Non-protected Glycopyranosides by the Dibutyltin Oxide Method
• The Alkaloidal Constituents of Goda-Manel (Crinum zeylanicum L.), a Sri Lankan Folk Medicine
• REGIOSELECTIVE MONO-OXIDATION OF NON-PROTECTED GLYCOSIDES BY THE BIS-TRIBUTYLTIN OXIDE-BROMINE METHOD
• 4,4-Dimethyl Effect. (6). The Ring A Conformation of 4,4-Dimethyl-3-keto Steroids and Triterpenoid-3-ketones : Predicted and Observed Geometries and Their Chiroptical Properties
• 4,4-Dimethyl Effect. (5). The Conformation of 8αH, 14βH-Onocerane-3,21-dione (Onoceranedione-I) in the Crystalline State
• アシル化糖の位置選択的合成とその転位 : 糖類水酸基の位置選択的修飾
• Solid Phase Synthesis of ψCH_2NH Pseudo-Peptide Analogs Using 2, 4-Dimethoxybenzyl Group as the Pseudobond Protecting Group
• On the Possibility of Direct O-1β→ -6 Acyl Migration in 1-O-Acyl-β-D-glucose Derivatives
• Identification of a Novel Carbohydrate-Mimicking Octapeptide from Chemical Peptide Library and Characterization as Selectin Inhibitor
• Protection of ψ(CH_2NH) Peptide Bond with 2,4-Dimethoxybenzyl Group in Solid-Phase Peptide Synthesis
• General Path of O-Acyl Migration in D-Glucose Derivatives : Acyl Migration of Methyl Mono-O-myristoyl-α- and β-D-Glucopyranosides and Mono-O-myristoyl-D-glucopyranoses
• Relationship between structure and P-glycoprotein inhibitory activity of dimeric opioid peptides containing the Dmt-Tic pharmacophore
• The Considerable Effects on Anti-tumor Activity and Cell Permeability of Small Peptides Containing Adamantyl Group
• エリスリナおよび関連アルカロイドの合成
• Receptor Affinity and Selectivity of Dermorphin-Related Analogs Containing 2', 6'-Dimethylphenylalanine in Position 1 or 3
• Synthesis of Bivalent Ac-RYYRIK-NH_2 Analogues and the Optimal Spacer Length for ORL1 Receptor Binding
• ショウブ根,セキショウ根に関する生薬学的研究(第2報) : アジア市場品Acorus属根茎に対する組織形態学的および化学的考察
• 色彩計による生薬の品質評価(第2報) : 大黄の色彩と含有成分量
• ネパール産カギカズラ属植物Uncaria scandensの形態とアルカロイド成分
• 色彩計による生薬の品質評価(第1報) : 粉末生薬の測定条件と人参類生薬の品質評価
• Novel [_D-Arg^2]dermorphin(1-4) Analogs with μ-Opioid Receptor Antagonist Activity
• ショウブ根,セキショウ根に関する生薬学的研究(1) : 日本産Acorus calamusおよびA. gramineus根茎の組織形態および精油成分
• ショウブ根, セキショウ根に関する生薬学的研究 (1) : 日本産 Acorus calamus および A. gramineus 根茎の組織形態および精油成分

もっと見る 閉じる

スポンサーリンク