Receptor Affinity and Selectivity of Dermorphin-Related Analogs Containing 2', 6'-Dimethylphenylalanine in Position 1 or 3

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概要

• 論文の詳細を見る
• 2003-02-01

著者

• AMBO Akihiro

  Tohoku Pharmaceutical University

• SASAKI Yusuke

  Tohoku Pharmaceutical University

• Sasaki Y

  Tohoku Pharmaceutical University

• NIIZUMA Hideko

  Tohoku Pharmaceutical University

• Sasaki Ai

  Tohoku Pharmaceutical University

• KOHARA Hirokazu

  Tohoku Pharmaceutical University

• Sasaki Yusuke

  Tohoku College Of Pharmacy

関連論文

• Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
• Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
• Sequence Analysis of Chinese and Japanese Curcuma Drugs on the 18S rRNA Gene and trnK Gene and the Application of Amplification-Refractory Mutation System Analysis for Their Authentication
• Molecular Analysis of Medicinally-Used Chinese and Japanese Curcuma Based on 18S rRNA Gene and trnK Gene Sequences
• Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
• Synthesis and Biological Activity of Opioid Peptides Replaced Phenylalanine at Position 3 or 4 by 2, 6-Dimethylphenylalanine
• Biological Properties of Opioid Peptides Replacing Tyr at Position 1 by 2,6-Dimethyl-Tyr
• Morphological, genetic, and chemical polymorphism of Curcuma kwangsiensis
• Application of Single-Nucleotide Polymorphism Analysis of the trnK Gene to the Identification of Curcuma Plants
• Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
• Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
• Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
• The Structure-Activity Relationship of Dmt-NH-X
• Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
• Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
• Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Their Activities
• Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
• Receptor Binding Properties and Antinociceptive Effects of Chimeric Peptides Consisting of a μ-Opioid Receptor Agonist and an ORL1 Receptor Antagonist(Medicinal Chemistry)
• Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
• The Structure-Activity Relationship of [Dmt^1]Endomorphin-2 Derivatives
• The Structure-Activity Relationship of the Opioidmimetics Containing 2(1H)-Pyrazinone Ring as a Linker and Observation of Deamination during Synthesis
• Design of Opioidmimetics : Dimerization of 2', 6'-Dimethyl-L-Tyrosine
• Nociceptin and Dynorphin A Analogues with Dmp Substituted for N-Terminal Aromatic Residues
• 2',6'-Dimethylphenylalanine (Dmp) Can Mimic the N-Terminal Tyr in Opioid Peptides(Medicinal Chemistry)
• Biological Activity of Dermorphin and Deltorphin-II Analogs Replaced Phenylalanine at Position 3 by 2,6-Dimethylphenylalanine
• Solid Phase Synthesis of ψCH_2NH Pseudo-Peptide Analogs Using 2, 4-Dimethoxybenzyl Group as the Pseudobond Protecting Group
• Identification of a Novel Carbohydrate-Mimicking Octapeptide from Chemical Peptide Library and Characterization as Selectin Inhibitor
• Protection of ψ(CH_2NH) Peptide Bond with 2,4-Dimethoxybenzyl Group in Solid-Phase Peptide Synthesis
• Relationship between structure and P-glycoprotein inhibitory activity of dimeric opioid peptides containing the Dmt-Tic pharmacophore
• Receptor Affinity and Selectivity of Dermorphin-Related Analogs Containing 2', 6'-Dimethylphenylalanine in Position 1 or 3
• Synthesis of Bivalent Ac-RYYRIK-NH_2 Analogues and the Optimal Spacer Length for ORL1 Receptor Binding
• Novel [_D-Arg^2]dermorphin(1-4) Analogs with μ-Opioid Receptor Antagonist Activity

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