Protection of ψ(CH_2NH) Peptide Bond with 2,4-Dimethoxybenzyl Group in Solid-Phase Peptide Synthesis
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概要
- 論文の詳細を見る
The reductive alkylation of a resin-bound amine by the Boc-amino aldehyde/NaBH_3CN method is accompanied with undesirable double alkylation at Xaaψ(CH_2NH)Gly sequences. To prevent the double alkylation, the utility of the 2,4-dimethoxybenzyl (Dmb) group for secondary amine protection was investigated. By using this group, Leu-enkephalin and dynorphin (1-8) analogs containing the ψ(CH_2NH) peptide bond between residues Tyr^1/Gly^2 or Gly^2/Gly^3 were synthesized in high yields.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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SASAKI Yusuke
Tohoku Pharmaceutical University
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Abe J
Process & Manufacturing Engineering Center Toshiba Corporation Semiconductor Company
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ABE Junko
Tohoku College of Pharmacy
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Sasaki Yusuke
Tohoku College Of Pharmacy
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