Anti-inflammatory and Anti-allergic Activities of Hydroxylamine and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
The anti-inflammatory activities of several novel oximes and O-acyl oximes that we synthesized have been reported based on carrageenan-induced rat foot-pad swelling assay and histamine-induced rat vascular permeability assay. A cyclooxygenase (COX)-1 inhibitory effect has also been reported for 4'-piperidinoacetophenone and 4'-morpholinoacetophenone oximes and their O-acyl derivatives. To further search for more effective nonsteroidal anti-inflammatory or anti-allergic drugs, 1-hydroxylamino-1-(4'-piperidinophenyl) ethane (P-HA) and 1-hydroxylamino-1-(4'-morpholinophenyl) ethane (M-HA) were synthesized from the corresponding oximes with sodium cyanoborohydride, and N,O-diacetyl hydroxylamines (P-HA-Ac and M-HA-Ac) were prepared from these hydroxylamines using acetyl chloride. These hydroxylamines and N,O-diacetyl hydroxylamines clearly exhibited inhibitory effects on mouse carrageenan-induced foot-pad swelling induced by oral administration (150, 37.5 mg/kg). An oral dose of P-HA-Ac (150 mg/kg) significantly inhibited the mouse anaphylactic reaction to ovalbumin measured by the abdominal wall (AW) method. Percutaneous administration of P-HA and M-HA significantly inhibited 2,4-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity reaction (type IV) in mice at a dose of 0.5 and 0.1 mg/ear, respectively. All tested hydroxylamines and N,O-diacetyl hydroxylamines clearly inhibited both COX-1 and COX-2 enzyme activities with IC_50 values of 1.9-28.7 and 1.6-2.9 μ_M against COX-1 and COX-2, respectively. Hydroxylamines (P-HA and M-HA) also showed a 5-lipoxygenase inhibitory effect.
- 社団法人日本薬学会の論文
- 2002-11-01
著者
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伊藤 裕二
Department Of Pharmaceutics Research Center Taisho Pharmaceutical Co. Ltd.
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Horiyama Shizuyo
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Womens University
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Semma Masanori
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Womens University
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Takayama Mitsuo
International Graduate School of Arts and Sciences, Yokohama City University
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Horiyama Shizuyo
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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Horiyama Shizuyo
武庫川女子大学 薬
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Semma Masanori
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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Takayama Mitsuo
International Graduate School Of Arts And Sciences Yokohama City University
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OKU Hisae
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Ito Yoshihisa
College Of Pharmacy Nihon University
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Kataoka Hiromi
School Of Pharmaceutical Sciences Mukogawa Women 's University
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Oku Hisae
School Of Pharmaceutical Sciences Mukogawa Women 's University
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ISHIGURO Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University
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YAMAKI Masae
School of Pharmaceutical Sciences, Mukogawa Women 's University
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KATAGI Toyoshi
School of Pharmaceutical Sciences, Mukogawa Women 's University
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TAKAYAMA Mitsuo
Graduate School of Sciences, Yokohama City University
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ITO Yoshio
School of Pharmaceutical Sciences, Mukogawa Women 's University
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Ito Yoshihisa
Res. Unit Of Pharmacology Dep. Of Clinical Pharmacy School Of Pharmacy Nihon Univ. Jpn
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Ishiguro Kyoko
School Of Pharmaceutical Sciences Mukogawa Women 's University
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加多木 豊之
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Ito Y
Nihon Univ. Funabashi Jpn
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Yamaki M
Mukogawa Women's Univ. Nishinomiya Jpn
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Yamaki Masae
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Katagi T
School Of Pharmaceutical Sciences Mukogawa Women 's University
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Takayama M
International Graduate School Of Arts And Sciences Yokohama City University
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Yamaki Masae
School Of Pharmaceutical Sciences Mukogawa Women 's University
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Ito Yuji
Otc Product R & D Research Laboratories Taisho Pharmaceutical Co. Ltd.
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TAKAYAMA Mitsuo
Graduate School in Nanobioscience, Yokohama City University
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