Allergy-Preventive Effects of Hibiscus mutabilis 'Versicolor' and a Novel Allergy-Preventive Flavonoid Glycoside(Pharmacognosy)
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概要
- 論文の詳細を見る
Allergy-preventive activity was demonstrated for the MeOH extract (HM) of the petals of Hibiscus mutabilis L. 'versicolor' MAKINO in a continuing search for allergy-preventive substances from natural sources, using the in vivo assay method. This assay system uses monitoring of a decrease in the blood flow at the tail vein of mice subjected to hen egg-white lysozyme (HEL) sensitization. By bioassay-directed fractionation, a new flavonol triglycoside, quercetin 3-O-[β-D-xylopyranosyl(1→2)-α-L-rhamnopyranosyl(1→6)]-β-D-galactopyranoside (1: mutabiloside), was isolated, together with four known flavonols identified as quercetin 3-O-[β-D-xylopyranosyl(1→2)]-β-D-galactopyranoside (2) and kaempferol 3-O-[β-D-xylopyranosyl(1→2)]-β-D-galactopyranoside (3), quercetin (4) and hyperoside (5). The structure of the new flavonol 1 was elucidated by spectroscopic methods. Among these flavonol derivatives, compounds 1 and 2 showed significant allergy-preventive effects.
- 公益社団法人日本薬学会の論文
- 2009-03-01
著者
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奥 尚枝
武庫川女大薬
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石黒 京子
武庫川女大薬
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OKU Hisae
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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石黒 京子
武庫川女子大学生薬学研究室
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Takahashi Yumi
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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Oku H
School Of Pharmaceutical Sciences Mukogawa Women's University
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Oku Hisae
School Of Pharmaceutical Sciences Mukogawa Women 's University
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ISHIGURO Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University
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Iwaoka Emiko
School Of Pharmaceutical Sciences Mukogawa Women's University
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Okamura Haruki
兵庫医科大学 病理学第一講座
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Ishiguro Kyoko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ.
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石黒 京子
Mukogawa Women's Univ. Nishinomiya Jpn
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石黒 京子
武庫川女子大学 薬
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Ishiguro Kyoko
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Ishiguro Kyoko
School Of Pharmaceutical Sciences Mukogawa Women 's University
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Oku Hisae
武庫川女子大学 薬学研究科
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Ito K
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Iwaoka Emiko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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Iwaoka Emiko
School Of Pharmaceutical Sciences Hyogo University Of Health Science
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