Antipruritic Effects of the Fruits of Chaenomeles sinensis
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概要
- 論文の詳細を見る
A 35% EtOH extract of the fruits of Chaenomeles sinensis, long utilized as a folk medicine for cough, significantly inhibited the pruritogenic agent compound 48/80 (COM)-induced scratching behavior in mice. Antipruritic activity-guided fractionation and purification yielded active quercetin, apigenin, and catechin derivatives, which exhibited significant inhibitory effects on COM-induced scratching behavior. To the best of our knowledge, apigenin (5), apigenin 7-glucronide (6), and apigenin 4'-methoxy-7-glucronide (acacetin 7-glucronide) (7) were isolated from the fruits of C. sinensis for the first time. The active fraction and these compounds also inhibited serotonin-, platelet activating factor-, and prostaglandin E_2-induced scratching behavior, but did not inhibit histamine-induced scratching behavior or locomotive behavior. This study also showed that the fruits of C. sinensis could be used to treat allergic itching sensation.
- 公益社団法人日本薬学会の論文
- 2003-07-01
著者
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奥 尚枝
武庫川女大薬
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石黒 京子
武庫川女大薬
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石黒 京子
武庫川女子大学生薬学研究室
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Oku H
School Of Pharmaceutical Sciences Mukogawa Women's University
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Oku Hisae
Mukogawa Women's University School Of Pharmaceutical Sciences
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Ishiguro Kyoko
Mukogawa Women's University School of Pharmaceutical Sciences
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Okamura Haruki
兵庫医科大学 病理学第一講座
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Ueda Yoshimi
School Of Pharmaceutical Sciences Mukogawa Women's University
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Ishiguro Kyoko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ.
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石黒 京子
Mukogawa Women's Univ. Nishinomiya Jpn
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石黒 京子
武庫川女子大学 薬
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Ishiguro Kyoko
Mukogawa Women's University School Of Pharmaceutical Sciences
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Ishiguro Kyoko
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Oku Hisae
武庫川女子大学 薬学研究科
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Ito K
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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UEDA Yoshimi
Mukogawa Women's University, School of Pharmaceutical Sciences
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Ueda Y
Showa Coll. Pharmaceutical Sci. Tokyo Jpn
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